Evidence map›Paper›PMID 33345466›Full record

ArticleMicrobiologyOpen2021

Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis.

Xianghai Zeng, Pengfei She, Linying Zhou, Shijia Li, Zubair Hussain, Lihua Chen, Yong Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianghai ZengDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Pengfei SheDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Linying ZhouDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Shijia LiDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Zubair HussainDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Lihua ChenDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.
Yong WuDepartment of Clinical Laboratory, The Third Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0002-3667-8716
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bacterium Enterococcus faecalis has increasingly attracted global attention as an important opportunistic pathogen due to its ability to form biofilms that are known to increase drug resistance. However, there are still no effective antibiofilm drugs in clinical settings. Here, by drug repurposing, we investigated the antibacterial activity of penfluridol (PF), an oral long-acting antipsychotic approved by the FDA, against E. faecalis type strain and its clinical isolates. It was found that PF inhibited the growth of E. faecalis planktonic cells with the MIC and MBC of 7.81 µg/ml and 15.63 ~ 62.50 µg/ml, respectively. Moreover, PF could significantly prevent the biofilm formation of E. faecalis at the concentration of 1 × MIC. Furthermore, PF significantly eradicated 24 h pre-formed biofilms of E. faecalis in a dose-dependent manner, with a concentration range of 1 × MIC to 8 × MIC. Here, through the checkerboard method with other tested conventional antibiotics, we also determined that gentamycin, penicillin G, and amikacin showed partial synergistic antibacterial effects with PF. Also, PF showed almost no hemolysis on human erythrocytes. In a mouse peritonitis model, a single dose of 20 mg/kg of PF treatment could significantly reduce the bacterial colonization in the liver (~5-fold reduction) and spleen (~3-fold reduction). In conclusion, these findings indicated that after structural optimization, PF has the potential as a new antibacterial agent against E. faecalis.

Indexed as

AnimalsAnti-Bacterial AgentsBiofilmsDisease Models, AnimalDrug RepositioningEnterococcus faecalisErythrocytesFemaleGram-Positive Bacterial InfectionsHumansMiceMice, Inbred ICRMicrobial Sensitivity TestsMicrobial ViabilityOpportunistic InfectionsPenfluridolAnti-Bacterial AgentsPenfluridolantibiofilmEnterococcus faecalisin vivopenfluridolrepurposing

Identifiers

PMID33345466
PMCPMC7884926
OpenAlexW3115174487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.