Evidence map›Paper›PMID 33345445›Full record

ArticleEMBO reports2021

Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis.

Miranda Y Fong, Wei Yan, Majid Ghassemian, Xiwei Wu, Xin Zhou, Minghui Cao, Li Jiang, Jessica Wang, Xuxiang Liu, Jin Zhang and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The significant role of amino acid metabolic reprogramming in cancer.Cell communication and signaling : CCS · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Miranda Y FongDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Wei YanDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Majid GhassemianBiomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, CA, USA.
Xiwei WuDepartment of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Xin ZhouDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Minghui CaoDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Li JiangDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Jessica WangDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Xuxiang LiuDepartment of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Jin ZhangDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Shizhen Emily WangDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5036-8175
University of California San Diego · USCity of Hope · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2M
Role of breast cancer-secreted miRNA in directing a stromal metabolic plasticityR01CA218140 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHIZHEN EMILY · 2017 to 2021
$2.4M
Targeting Chemotherapy-induced Breast Cancer StemnessR01CA206911 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHIZHEN EMILY, YUAN, YUAN · 2017 to 2021
$2.3M
NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA033572NCI NIH HHS P30CA23100NCI NIH HHS P30CA33572NCI NIH HHS R01 CA206911NCI NIH HHS R01CA206911NCI NIH HHS R01 CA218140NCI NIH HHS R01CA218140NCI NIH HHS R35 CA197622NCI NIH HHS R35CA197622
6 · The paper itself

Abstract

Metabolic reprogramming of non-cancer cells residing in a tumor microenvironment, as a result of the adaptations to cancer-derived metabolic and non-metabolic factors, is an emerging aspect of cancer-host interaction. We show that in normal and cancer-associated fibroblasts, breast cancer-secreted extracellular vesicles suppress mTOR signaling upon amino acid stimulation to globally reduce mRNA translation. This is through delivery of cancer-derived miR-105 and miR-204, which target RAGC, a component of Rag GTPases that regulate mTORC1 signaling. Following amino acid starvation and subsequent re-feeding,

Indexed as

MicroRNAsMonomeric GTP-Binding ProteinsNeoplasmsAmino AcidsFibroblastsHumansMechanistic Target of Rapamycin Complex 1Amino AcidsMechanistic Target of Rapamycin Complex 1MicroRNAsMIRN105 microRNA, humanMIRN204 microRNA, humanMonomeric GTP-Binding Proteinsbreast cancerextracellular vesiclesmicroRNAmRNA translationmTORC1

Identifiers

PMID33345445
PMCPMC7857427
OpenAlexW3117339865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.