Evidence map›Paper›PMID 33345405›Full record

ArticleJournal of veterinary internal medicine2021

Comprehensive comparison of upper and lower endoscopic small intestinal biopsy in cats with chronic enteropathy.

Betty Chow, Steve L Hill, Keith P Richter, Sina Marsilio, Mark R Ackermann, Jonathan A Lidbury, Jan S Suchodolski, Sarah Cocker, Jörg M Steiner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Betty ChowVeterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.ORCID https://orcid.org/0000-0002-7775-3719
Steve L HillVeterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.
Keith P RichterVeterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.
Sina MarsilioDepartment of Medicine and Epidemiology, University of California, School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0002-0693-0669
Mark R AckermannDepartment of Biomedical Sciences and Oregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Jonathan A LidburyGastrointestinal Laboratory, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0001-5107-4577
Jan S SuchodolskiGastrointestinal Laboratory, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-2176-6932
Sarah CockerVeterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.ORCID https://orcid.org/0000-0002-8110-8894
Jörg M SteinerGastrointestinal Laboratory, Texas A&M University, College Station, Texas, USA.ORCID https://orcid.org/0000-0003-3336-2086
Orthopedic Specialty Hospital · USTexas A&M University · USOregon State University · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntegrating immunohistochemistry (IHC) and clonality testing with histopathology may improve the ability to differentiate inflammatory bowel disease (IBD) and alimentary small cell lymphoma (LSA) in cats. HYPOTHESIS/

objectivesTo evaluate the utility of histopathology, IHC, and clonality testing to differentiate between IBD and LSA and agreement of diagnostic results for endoscopic biopsy (EB) samples from the upper (USI) and lower small intestine (LSI). ANIMALS: Fifty-seven cats with IBD or LSA.

methodsAll cases were categorized as definitive IBD (DefIBD), possible LSA (PossLSA), probable LSA (ProbLSA), or definitive LSA (DefLSA) based on histopathology alone. Results from IHC and clonality testing were integrated.

resultsBased on histopathology alone, 24/57 (42.1%), 15/57 (26.3%), and 18/57 (31.6%) cats were diagnosed with DefIBD, PossLSA or ProbLSA, and DefLSA, respectively. After integrating IHC and clonality testing, 11/24 cases (45.8%) and 15/15 cases (100%) previously categorized as DefIBD and PossLSA or ProbLSA, respectively, were reclassified as LSA. A final diagnosis of IBD and LSA was reported in 13/57 (22.8%) and 44/57 (77.2%) cats, respectively. Agreement between USI and LSI samples was moderate based on histopathology alone (κ = 0.66) and after integrating IHC and clonality testing (κ = 0.70). However, only 1/44 (2.3%) of the LSA cases was diagnosed based on LSI biopsy alone. CONCLUSIONS AND CLINICAL IMPORTANCE: Integrating IHC and clonality testing increased the number of cases diagnosed with LSA, but the consequence for patient outcome is unclear. There was moderate agreement between USI and LSI samples. Samples from the LSI rarely changed the diagnosis.

Indexed as

Cat DiseasesInflammatory Bowel DiseasesLeukemia, Lymphocytic, Chronic, B-CellAnimalsBiopsyCatsIntestinesIntestine, Smallclonalityfeline chronic enteropathyimmunohistochemistryinflammatory bowel diseasePARRsmall cell lymphoma

Identifiers

PMID33345405
PMCPMC7848359
OpenAlexW3117491197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.