Evidence map›Paper›PMID 33345333›Full record

ArticleEpilepsia2020

Topological alterations in older adults with temporal lobe epilepsy are distinct from amnestic mild cognitive impairment.

Erik Kaestner, Anny Reyes, Zhong Irene Wang, Daniel L Drane, Vineet Punia, Bruce Hermann, Robyn M Busch, Carrie R McDonald, Alzheimer's Disease Neuroimaging Initiative

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Erik KaestnerCenter for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0003-3252-5365
Anny ReyesCenter for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0003-0625-6990
Zhong Irene WangEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-3829-5217
Daniel L DraneDepartments of Neurology and Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-8747-672X
Vineet PuniaEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0552-6736
Bruce HermannDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0003-0133-4427
Robyn M BuschEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-5442-4912
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, USA.
Alzheimer's Disease Neuroimaging Initiative
Cleveland Clinic · USSan Diego State University · USAlzheimer’s Disease Neuroimaging Initiative · USEmory University · USUniversity of California San Diego · USUniversity of Wisconsin–Madison · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Multimodal imaging of memory reorganization in epilepsy from whole brain networks to local neuronal responses: Implications for surgical-decision-makingR56NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2020 to 2020
$467k
Explaining cognitive heterogeneity in temporal lobe epilepsy (TLE): Identifying unique imaging features, health-related risk factors and protective factors in TLE subtypesF31NS111883 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI REYES, ANNY · 2019 to 2021
$89k
AbbVieAlzheimer's AssociationAlzheimer's Drug Discovery FoundationAraclon BiotechBioClinicaBiogenBristol-Myers Squibb CompanyCereSpirCogstateCorporationDepartment of Defense W81XWH-12-2-0012EisaiElanEli Lilly and CompanyEuroImmunF. Hoffmann-La Roche and its affiliated company GenentechFujirebioGE HealthcareHealth ResearchIXICOJanssen Alzheimer Immunotherapy Research & DevelopmentJohnson & Johnson Pharmaceutical Research & DevelopmentLumosityLundbeckMerck & Co.Meso Scale DiagnosticsNeuroRx ResearchNeurotrack TechnologiesNIA NIH HHS U01 AG024904NIBIB NIH HHSNIH HHSNIMH NIH HHS R01 MH118514NIMH NIH HHS T32 MH018399NINDS NIH HHS F31 NS111883NINDS NIH HHS MH018399NINDS NIH HHS NS065838NINDS NIH HHS NS088748NINDS NIH HHS NS111883NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS088748Northern California Institute for Research and EducationNovartisPfizerPharmaceuticalsPiramal ImagingServierTakeda Pharmaceutical CompanyThe Canadian Institutes ofTransition Therapeutics
6 · The paper itself

Abstract

Epilepsy incidence and prevalence peaks in older adults, yet systematic studies of brain aging and epilepsy remain limited. We investigated topological network disruption in older adults with temporal lobe epilepsy (TLE; age > 55 years). Additionally, we examined the potential network disruption overlap between TLE and amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer disease. Measures of network integration ("global path efficiency") and segregation ("transitivity" and "modularity") were calculated from cortical thickness covariance from 73 TLE subjects, 79 aMCI subjects, and 70 healthy controls. Compared to controls, TLE patients demonstrated abnormal measures of segregation (increased transitivity and decreased modularity) and integration (decreased global path efficiency). aMCI patients also displayed increased transitivity and decreased global path efficiency, but these differences were less pronounced than in TLE. At the local level, TLE patients demonstrated decreased local path efficiency focused in the bilateral temporal lobes, whereas aMCI patients had a more frontal-parietal distribution. These results suggest that network disruption at the global and local level is present in both disorders, but global disruption may be a particularly salient feature in older adults with TLE. These findings motivate further research into whether these network changes have distinct cognitive correlates or are progressive in older adults with epilepsy.

Indexed as

AgedAmnesiaBrain MappingCerebral CortexCognitive DysfunctionEpilepsy, Temporal LobeFemaleFollow-Up StudiesHumansMaleMiddle AgedNerve Netamnestic mild cognitive impairmentgraph theoryolder adultstemporal lobe epilepsy

Identifiers

PMID33345333
PMCPMC8000506
OpenAlexW3094166175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.