Evidence map›Paper›PMID 33345332›Full record

ArticleEuropean journal of immunology2021

Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein.

Judith Leitner, Kodchakorn Mahasongkram, Philipp Schatzlmaier, Karin Pfisterer, Vladimir Leksa, Supansa Pata, Watchara Kasinrerk, Hannes Stockinger, Peter Steinberger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Oligoclonal CD4Communications biology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Judith LeitnerDivision of Immune Receptors and T Cell Activation, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-7156-1759
Kodchakorn MahasongkramDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Philipp SchatzlmaierInstitute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-0555-8866
Karin PfistererInstitute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1723-6266
Vladimir LeksaInstitute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Supansa PataDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Watchara KasinrerkDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0003-0316-1531
Hannes StockingerInstitute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6404-4430
Peter SteinbergerDivision of Immune Receptors and T Cell Activation, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6848-4097
Medical University of Vienna · ATNational Science and Technology Development Agency · THChiang Mai University · THSlovak Academy of Sciences · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upon generation of monoclonal antibodies to the T cell antigen receptor/CD3 (TCR/CD3) complex, we isolated mAb MT3, whose reactivity correlates inversely with the production of IFN-γ by human peripheral blood T lymphocytes. Using eukaryotic expression cloning, we identified the MT3 antigen as myelin-and-lymphocyte (MAL) protein. Flow cytometry analysis demonstrates high surface expression of MAL on all naïve CD4

Indexed as

AnimalsCD28 AntigensCD3 ComplexCD4-Positive T-LymphocytesCell DifferentiationCell Line, TumorFlow CytometryGene ExpressionHumansInterferon-gammaJurkat CellsLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMyelin and Lymphocyte-Associated Proteolipid ProteinsPhosphorylationCD28 AntigensCD3 ComplexInterferon-gammaLymphocyte Specific Protein Tyrosine Kinase p56(lck)Myelin and Lymphocyte-Associated Proteolipid ProteinsReceptors, Antigen, T-CellTumor Necrosis Factor-alphaCD4DifferentiationHumanMALT-cell activation

Identifiers

PMID33345332
PMCPMC8248321
OpenAlexW3114841130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.