Evidence map›Paper›PMID 33345326›Full record

ArticleJournal of cellular physiology2021

Distinct temporal actions of different types of unfolded protein responses during aging.

Yi Sheng, Guang Yang, Zachary Markovich, Sung Min Han, Rui Xiao

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Redox regulation of UPR signalling and mitochondrial ER contact sites.Cellular and molecular life sciences : CMLS · 2024
    Review
  4. Cardiovascular aging: the mitochondrial influence.The journal of cardiovascular aging · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yi ShengDepartment of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Guang YangDepartment of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Zachary MarkovichDepartment of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Sung Min HanDepartment of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Rui XiaoDepartment of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5541-6685
University of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Dissecting the mechanisms of Alzheimer's disease (AD)-related smell loss in a C. elegans AD modelR01AG063766 · NIA · UNIVERSITY OF FLORIDA · PI XIAO, RUI · 2019 to 2023
$1.9M
The role and regulation of mitochondrial localization in mature neurons.R01AG081270 · NIA · UNIVERSITY OF FLORIDA · PI SUNG MIN HAN · 2023 to 2026
$1.5M
Understanding the role of mitochondria in the age-related decline in axon regenerationR56AG066654 · NIA · UNIVERSITY OF FLORIDA · PI HAN, SUNG MIN · 2020 to 2020
$375k
NIA NIH HHS AG028740NIA NIH HHS AG063766NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG063766NIA NIH HHS R01 AG081270NIA NIH HHS R56 AG066654NIH HHS P40 OD010440
6 · The paper itself

Abstract

Proteotoxic stress is a common challenge for all organisms. Among various mechanisms involved in defending such stress, the evolutionarily conserved unfolded protein responses (UPRs) play a key role across species. Interestingly, UPRs can occur in different subcellular compartments including the endoplasmic reticulum (UPR

Indexed as

AgingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCytoplasmEndoplasmic ReticulumLongevityMitochondriaRNA InterferenceSignal TransductionUnfolded Protein ResponseCaenorhabditis elegans Proteinsagingcytosolic UPRendoplasmic reticulum UPRmitochondrial UPRstresstemporal

Identifiers

PMID33345326
PMCPMC8026671
OpenAlexW3114102288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.