NKCC1: Newly Found as a Human Disease-Causing Ion Transporter.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

33 citing papers in PubMed, 58 citations in OpenAlex.

1. Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review.Health science reports · 2026
   Article
2. Ion Channel Integration and Functional Coupling in Salivary Gland Fluid Secretion.Cells · 2026
   Review
3. CRISPR and gene editing for kidney diseases: where are we?Clinical kidney journal · 2025
   Review
4. Regional atrophy, cellular plasticity, and regenerative potential in irradiated murine salivary glands.Acta oncologica (Stockholm, Sweden) · 2025
   Article
5. The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland.iScience · 2025
   Article
6. Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures.Frontiers in neuroscience · 2025
   Article
7. Continuous Use During Disuse: Mechanisms and Effects of Spontaneous Activity of Unloaded Postural Muscle.International journal of molecular sciences · 2024
   Review
8. Aqueous extract of Descuraniae Semen attenuates lipopolysaccharide-induced inflammation by inhibiting ER stress and WNK4-SPAK-NKCC1 pathway.Journal of cellular and molecular medicine · 2024
   Article
9. The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss.International journal of molecular sciences · 2024
   Review
10. State of knowledge on ammonia handling by the kidney.Pflugers Archiv : European journal of physiology · 2024
    Review
11. NKCC1 in human diseases: is theAmerican journal of physiology. Cell physiology · 2023
    Article
12. Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.Fluids and barriers of the CNS · 2023
    Article
13. Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review.International journal of molecular sciences · 2023
    Review
14. Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.Neuron · 2023
    Article
15. Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases.Molecular brain · 2023
    Article
16. NaPhysiological genomics · 2023
    Article
17. Preclinical Development of the Na-K-2Cl Co-transporter-1 (NKCC1) Inhibitor ARN23746 for the Treatment of Neurodevelopmental Disorders.ACS pharmacology & translational science · 2023
    Article
18. Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.The EMBO journal · 2022
    Article
19. Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy.Scientific reports · 2022
    Article
20. Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.Science advances · 2022
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 1 institution in 1 country.

Funding

Abstract

Indexed as