Evidence map›Paper›PMID 33344923›Full record

ArticleiScience2020

Imaging Acute Metabolic Changes in Patients with Mild Traumatic Brain Injury Using Hyperpolarized [1-

Edward P Hackett, Marco C Pinho, Crystal E Harrison, Galen D Reed, Jeff Liticker, Jaffar Raza, Ronald G Hall, Craig R Malloy, Surendra Barshikar, Christopher J Madden and 1 more

Abstract read
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  3. The microdialysis-derived lactate-pyruvate gradient indicates anaerobic activity after brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  4. Article
  5. HyperpolarizedResearch square · 2026
    Article
  6. Review
  7. Stable electron-irradiated [1-Science advances · 2025
    Article
  8. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
  9. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  10. Article
  11. Hyperpolarized [1-Brain communications · 2025
    Article
  12. Article
  13. Article
  14. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  15. Review
  16. Tracing the path of disruption:CNS neuroscience & therapeutics · 2024
    Review
  17. Article
  18. Article
  19. Hyperpolarized [2-NeuroImage · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edward P HackettAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Marco C PinhoAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Crystal E HarrisonAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Galen D ReedAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jeff LitickerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jaffar RazaDepartment of Pharmacy Practice, The Texas Tech University Health Sciences Center, Dallas, TX 75216, USA.
Ronald G HallDepartment of Pharmacy Practice, The Texas Tech University Health Sciences Center, Dallas, TX 75216, USA.
Craig R MalloyAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Surendra BarshikarDepartment of Physical Medicine & Rehabilitation, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Christopher J MaddenDepartment of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
NIBIB NIH HHS P41 EB015908NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

Traumatic brain injury (TBI) involves complex secondary injury processes following the primary injury. The secondary injury is often associated with rapid metabolic shifts and impaired brain function immediately after the initial tissue damage. Magnetic resonance spectroscopic imaging (MRSI) coupled with hyperpolarization of

Indexed as

Biological SciencesClinical NeuroscienceMolecular NeuroscienceNeuroscienceTechniques in Neuroscience

Identifiers

PMID33344923
PMCPMC7736977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.