Evidence map›Paper›PMID 33344796›Full record

ReviewNutrition and healthy aging2020

Moonshots for aging.

Sandeep Kumar, Timothy R Peterson

Abstract readReview
In one paragraph

Review in Nutrition and healthy aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sandeep KumarDepartment of Internal Medicine, Division of Bone and Mineral Diseases, Department of Genetics, Institute for Public Health, Washington University School of Medicine, BJC Institute of Health, MO, USA.
Timothy R PetersonDepartment of Internal Medicine, Division of Bone and Mineral Diseases, Department of Genetics, Institute for Public Health, Washington University School of Medicine, BJC Institute of Health, MO, USA.

Funding

Novel insulin-sensitizing NASH/diabetes drugs.R42DK121652 · NIDDK · BIOIO, LLC · PI FINCK, BRIAN N, PETERSON, TIMOTHY R · 2019 to 2022
$1.7M
Genetic Factors of Bone Loss in Older Adults Taking AntidepressantsR01AR073017 · NIAMS · WASHINGTON UNIVERSITY · PI PETERSON, TIMOTHY R · 2018 to 2021
$1.6M
TBONE and phosphonates in mineralization during agingR00AG047255 · NIA · WASHINGTON UNIVERSITY · PI PETERSON, TIMOTHY R · 2016 to 2018
$725k
TBONE and phosphonates in mineralization during agingK99AG047255 · NIA · HARVARD UNIVERSITY · PI PETERSON, TIMOTHY R · 2014 to 2015
$231k
Drug target identification using CRISPRi/a screeningR41GM137625 · NIGMS · BIOIO, LLC · PI GILBERT, LUKE, PETERSON, TIMOTHY R · 2020 to 2020
$224k
NIAMS NIH HHS R01 AR073017NIA NIH HHS K99 AG047255NIA NIH HHS R00 AG047255NIDDK NIH HHS R42 DK121652NIGMS NIH HHS R41 GM137625
6 · The paper itself

Abstract

As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn't know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though "shot" might imply medicine, perhaps we need to think beyond medical interventions. Like the moon once was, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one's life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research.

Identifiers

PMID33344796
PMCPMC7740370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.