Evidence map›Paper›PMID 33344730›Full record

ArticleNeurobiology of stress2020

Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles.

Meghan Donovan, Calvin S Mackey, Grayson N Platt, Jacob Rounds, Amber N Brown, Darryl J Trickey, Yan Liu, Kathryn M Jones, Zuoxin Wang

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 104 citations in OpenAlex.

  1. The prairie vole gut-brain-microbiota-axis: a narrative review.Gut microbiome (Cambridge, England) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Social Housing of Postoperative Animals to Support Animal Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Father's care uniquely influences male neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Shared Evolutionary Path in Social Microbiomes.Molecular biology and evolution · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Meghan DonovanDepartment of Psychology and Program in Neuroscience, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA.
Calvin S MackeyDepartment of Biological Science, Florida State University, 319 Stadium Dr., Tallahassee, FL, 32306, USA.
Grayson N PlattDepartment of Psychology and Program in Neuroscience, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA.
Jacob RoundsDepartment of Psychology and Program in Neuroscience, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA.
Amber N BrownDepartment of Biological Science Core Facilities, Florida State University, 319 Stadium Dr., Tallahassee, FL, 32306, USA.
Darryl J TrickeyDepartment of Biological Science, Florida State University, 319 Stadium Dr., Tallahassee, FL, 32306, USA.
Yan LiuDepartment of Psychology and Program in Neuroscience, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA.
Kathryn M JonesDepartment of Biological Science, Florida State University, 319 Stadium Dr., Tallahassee, FL, 32306, USA.
Zuoxin WangDepartment of Psychology and Program in Neuroscience, Florida State University, 1107 W. Call St., Tallahassee, FL, 32306, USA.
Florida State University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Integrated Clinical Neuroscience Training for Translational ResearchT32MH093311 · NIMH · FLORIDA STATE UNIVERSITY · PI LISA A ECKEL, Pamela K. Keel · 2012 to 2026
$2.3M
Epigenetics of social bonding in prairie volesR01MH109450 · NIMH · FLORIDA STATE UNIVERSITY · PI KABBAJ, MOHAMED, WANG, ZUOXIN · 2016 to 2020
$1.9M
Stress, social buffering, and oxytocin regulationR01MH108527 · NIMH · FLORIDA STATE UNIVERSITY · PI WANG, ZUOXIN · 2017 to 2021
$1.9M
Exploring the epigenetic effects on male parental behaviorR21MH111998 · NIMH · FLORIDA STATE UNIVERSITY · PI WANG, ZUOXIN · 2018 to 2019
$422k
NIMH NIH HHS R01 MH108527NIMH NIH HHS R01 MH109450NIMH NIH HHS R21 MH111998NIMH NIH HHS T32 MH093311
6 · The paper itself

Abstract

The absence of social support, or social isolation, can be stressful, leading to a suite of physical and psychological health issues. Growing evidence suggests that disruption of the gut-immune-brain axis plays a crucial role in the negative outcomes seen from social isolation stress. However, the mechanisms remain largely unknown. The socially monogamous prairie vole (

Indexed as

AnaeroplasmaGut microbiome-immune-brain axisMicrogliaOxytocinSex differenceSocial isolation

Identifiers

PMID33344730
PMCPMC7739176
OpenAlexW3109904342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.