ArticleNeurobiology of stress2020
A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity.
Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 44 citations in OpenAlex.
- Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice.Alcohol, clinical & experimental research · 2026Article
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence.bioRxiv : the preprint server for biology · 2026Article
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.Translational psychiatry · 2026Article
- Post-Traumatic Stress Disorder and Alcohol Consumption: Biological Mechanisms of Stress Resilience to Subsequent Alcohol Consumption.Alcohol research : current reviews · 2026Review
- Alcohol use disorder-associated pain: clinical and preclinical evidence.Alcohol (Fayetteville, N.Y.) · 2025Review
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.bioRxiv : the preprint server for biology · 2025Article
- Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI.Alcohol, clinical & experimental research · 2025Article
- Early life stress modulates behavioral sensitivity to alcohol and promotes escalation of alcohol drinking.bioRxiv : the preprint server for biology · 2025Article
- KAlcohol (Fayetteville, N.Y.) · 2025Article
- Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.Alcohol (Fayetteville, N.Y.) · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density.Brain, behavior, & immunity - health · 2025Article
- Impacts of chronic intermittent ethanol vapor and predator odor on ethanol intake and striatal DFrontiers in neuroscience · 2025Article
- Sex differences in basal motivated behavior, chronic ethanol drinking, and amygdala activity in female and male mice.Alcohol (Fayetteville, N.Y.) · 2024Article
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- Limited bedding and nesting increases ethanol drinking in female rats.Pharmacology, biochemistry, and behavior · 2024Article
- The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.Neurobiology of stress · 2024Article
- Histone deacetylase inhibitor decreases hyperalgesia in a mouse model of alcohol withdrawal-induced hyperalgesia.Alcohol, clinical & experimental research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Childhood adversity increases vulnerability to alcohol use disorders and preclinical models are needed to investigate the underlying neurobiological mechanisms. The present study modeled early-life adversity by rearing male and female C57BL/6J mouse pups in a limited bedding and nesting (LBN) environment, which induces erratic maternal care. As adults, mice were given limited access to two-bottle choice (2BC) alcohol drinking, combined or not with chronic intermittent ethanol (CIE) vapor inhalation to induce alcohol dependence. We tested the hypothesis that LBN rearing might exacerbate or facilitate the emergence of the motivational and affective effects of CIE. Consistent with our hypothesis, although LBN-reared males consumed the same baseline levels of alcohol as controls, they escalated their ethanol intake at an earlier stage of CIE exposure, i.e., after 4 rounds vs. 5 rounds for controls. In contrast, females were insensitive to both LBN rearing and CIE exposure. Males were further subjected to a behavioral test battery. Withdrawal from CIE-2BC increased digging activity and lowered mechanical nociceptive thresholds regardless of early-life conditions. On the other hand, LBN-reared CIE-2BC males showed reduced open arm exploration in the elevated plus maze and increased immobility in the tail suspension test compared to alcohol-naïve counterparts, while no group differences were detected among control-reared males. Finally, LBN rearing and alcohol exposure did not affect grooming in response to a sucrose spray (splash test), novel object recognition, or corticosterone levels. In summary, the LBN experience accelerates the transition from moderate to excessive alcohol drinking and produces additional indices of affective dysfunction during alcohol withdrawal in C57BL/6J male mice.
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