Evidence map›Paper›PMID 33344718›Full record

ArticleNeurobiology of stress2020

Maternal stress programs accelerated aging of the basal ganglia motor system in offspring.

Jordan Marrocco, Remy Verhaeghe, Domenico Bucci, Luisa Di Menna, Anna Traficante, Hammou Bouwalerh, Gilles Van Camp, Veronica Ghiglieri, Barbara Picconi, Paolo Calabresi and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Jordan MarroccoHarold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 10065, NY, USA.
Remy VerhaegheIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Domenico BucciIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Luisa Di MennaIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Anna TraficanteIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Hammou BouwalerhUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Gilles Van CampUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Veronica GhiglieriIRCCS Santa Lucia Foundation, Laboratory of Neurophysiology, via del Fosso di Fiorano, 64, 00143, Rome, Italy.
Barbara PicconiLaboratory of Experimental Neurophysiology, IRCCS San Raffaele Pisana, Rome, Italy.
Paolo CalabresiNeurologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Piazzale Agostino Gemelli 8, 00168, Rome, Italy.
Laura RavasiEA1046, IMPRT-IFR114, Faculty of Medicine, University of Lille, 59000, Lille, France.
Francesca CisaniUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Farzaneh BagheriUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Anna PittalugaDept. of Pharmacology, School of Medical and Pharmaceutical Sciences, Center of Excellence for Biochemical Research (CEBR), University of Genova, Italy.
Valeria BrunoIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Giuseppe BattagliaIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Sara Morley-FletcherUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Ferdinando NicolettiIRCCS Neuromed, Località Camerelle, 86077, Pozzilli, Italy.
Stefania MaccariUniv. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000, Lille, France.
Istituto Neurologico Mediterraneo · ITCentre National de la Recherche Scientifique · FRAgostino Gemelli University Polyclinic · ITIRCCS Ospedale San Raffaele · ITOspedale Policlinico San Martino · ITRockefeller University · USUniversité de Lille · FRUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male rats. Adult PRS offspring rats showed reduced dopamine (DA) release in the striatum associated with reductions in tyrosine hydroxylase-positive (TH

Indexed as

Adenosine receptorsAgingIntegrated studyMotor behaviorNigrostriatal developmentSynaptic proteins

Identifiers

PMID33344718
PMCPMC7739146
OpenAlexW3094711802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.