ArticleNeurobiology of stress2020
Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice.
Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Multiple-context extinction strengthens fear suppression through hippocampal dopamine D2R-dependent memory updating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Variation in cocaine responses across genetically diverse mouse strains.Psychopharmacology · 2026Article
- Acarbose improves cognitive function in a mouse model of normal aging but not Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- The Impact of Overexpression of the Mouse Ortholog ofBiological psychiatry global open science · 2025Article
- Quantifying social roles in multi-animal videos using subject-aware deep-learning.bioRxiv : the preprint server for biology · 2024Article
- Ghrelin receptor agonist MK0677 and overnight fasting do not rescue deficient fear extinction in 129S1/SvImJ mice.Frontiers in psychiatry · 2023Article
- A Moderate Duration of Stress Promotes Behavioral Adaptation and Spatial Memory in Young C57BL/6J Mice.Brain sciences · 2022Article
- Tissue Plasminogen Activator in Central Nervous System Physiology and Pathology: From Synaptic Plasticity to Alzheimer's Disease.Seminars in thrombosis and hemostasis · 2022Review
- Using deep learning to study emotional behavior in rodent models.Frontiers in behavioral neuroscience · 2022Review
- CB2 cannabinoid receptor expression is increased in 129S1/SvImJ mice: behavioral consequences.Frontiers in pharmacology · 2022Article
- Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Altered sleep behavior in a genetic mouse model of impaired fear extinction.Scientific reports · 2021Article
- An open-source device for measuring food intake and operant behavior in rodent home-cages.eLife · 2021Article
- A New Look at Infant Problem-Solving: Using DeepLabCut to Investigate Exploratory Problem-Solving Approaches.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Acute physical or psychological stress can elicit adaptive behaviors that allow an organism maintain homeostasis. However, intense and/or prolonged stressors often have the opposite effect, resulting in maladaptive behaviors and curbing goal-directed action; in the extreme, this may contribute to the development of psychiatric conditions like generalized anxiety disorder, major depressive disorder, or post-traumatic stress disorder. While treatment of these disorders generally focuses on reducing reactivity to potentially threatening stimuli, there are in fact impairments across multiple domains including valence, arousal, and cognition. Here, we use the genetically stress-susceptible 129S1 mouse strain to explore the effects of stress across multiple domains. We find that 129S1 mice exhibit a potentiated neuroendocrine response across many environments and paradigms, and that this is associated with reduced exploration, neophobia, decreased novelty- and reward-seeking, and spatial learning and memory impairments. Taken together, our results suggest that the 129S1 strain may provide a useful model for elucidating mechanisms underlying myriad aspects of stress-linked psychiatric disorders as well as potential treatments that may ameliorate symptoms.
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