ArticleNeurobiology of stress2020
Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis.
Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Neurobehavioral mechanisms of fear and anxiety in multiple sclerosis.Communications medicine · 2025Article
- Body mass, neuro-hormonal stress processing, and disease activity in lean to obese people with multiple sclerosis.Journal of neurology · 2024Article
- Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024Review
- Similar neural pathways link psychological stress and brain-age in health and multiple sclerosis.iScience · 2023Article
- Central stress processing, T-cell responsivity to stress hormones and disease severity in multiple sclerosis.Brain communications · 2022Article
- Prefrontal-amygdala emotion regulation and depression in multiple sclerosis.Brain communications · 2022Article
- Article
- Network Damage Predicts Clinical Worsening in Multiple Sclerosis: A 6.4-Year Study.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis.Frontiers in neurology · 2021Article
- The Role of Stress Perception and Coping with Stress and the Quality of Life Among Multiple Sclerosis Patients.Psychology research and behavior management · 2021Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is characterized by two neuropathological key aspects: inflammation and neurodegeneration. Clinical studies support a prospective link between psychological stress and subsequent inflammatory disease activity. However, it is unknown if a similar link exists for grey matter (GM) degeneration as the key driver of irreversible disability.
methodsWe tested whether neural network activity triggered in a psychological fMRI stress paradigm (a mental arithmetic task including social evaluation) conducted at a baseline time point predicts future GM atrophy in 25 persons with MS (14 females). Atrophy was determined between the baseline and a follow-up time point with a median delay of 1012 (Rg: 717-1439) days. Additionally, atrophy was assessed in 22 healthy subjects (13 females; median delay 771 [Rg: 740-908] days between baseline and follow-up) for comparison.
resultsAn analysis of longitudinal atrophy in patients revealed GM loss in frontal, parietal, and cerebellar areas. Cerebellar atrophy was more pronounced in patients than controls. Future parietal and cerebellar atrophy could be predicted based on activity of two networks. Perceived psychological stress was negatively related to future parietal atrophy in patients and activity of the network predictive of parietal atrophy was positively linked to perceived stress.
conclusionsWe have shown that blunted neural and psychological stress processing have a detrimental effect on the course of MS and are interrelated. Together with research showing that psychological and neural stress processing can be altered through interventions, our findings suggest that stress processing might constitute an important modifiable disease factor.
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