Evidence map›Paper›PMID 33344693›Full record

ArticleNeurobiology of stress2020

Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress.

Miyoung Yang, Qi Ding, Ming Zhang, Changjong Moon, Hongbing Wang

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  8. CaFrontiers in pharmacology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Miyoung YangDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Qi DingDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Ming ZhangDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Changjong MoonDepartment of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, South Korea.
Hongbing WangDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Michigan State University · USChonnam National University · KRWonkwang University · KR

Funding

Nonconventional role of ADCY in Gq-mediated neuronal signaling and neuroplasticityR01MH119149 · NIMH · MICHIGAN STATE UNIVERSITY · PI WANG, HONGBING · 2019 to 2023
$2.3M
NIMH NIH HHS R01 MH119149
6 · The paper itself

Abstract

The ability to cope with stress is essential for emotional stability and mental health. It is also hypothesized that factors promoting resilience to stress may offer treatment strategies for maladaptive disorders such as anxiety and depression. Here, we find that physical restraint reduces the expression of type 1 adenylyl cyclase (

Indexed as

AntidepressantBrain-derived neurotrophic factorCorticosteroneGlucocorticoid receptorPhysical restraintStress resilienceType I adenylyl Cyclase

Identifiers

PMID33344693
PMCPMC7739041
OpenAlexW3038121731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.