Evidence map›Paper›PMID 33344666›Full record

ArticleOrthopaedic journal of sports medicine2020

VEGFA Promoter Polymorphisms rs699947 and rs35569394 Are Associated With the Risk of Anterior Cruciate Ligament Ruptures Among Indian Athletes: A Cross-sectional Study.

Manish Shukla, Rahul Gupta, Vivek Pandey, Jacques Rochette, Perundurai S Dhandapany, Pramod Kumar Tiwari, Rabbind Singh Amrathlal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Manish ShuklaDepartment of Exercise Physiology, Lakshmibai National Institute of Physical Education, Gwalior, India.
Rahul GuptaCentre for Genomics, Molecular & Human Genetics, Jiwaji University, Gwalior, India.
Vivek PandeyDepartment of Exercise Physiology, Lakshmibai National Institute of Physical Education, Gwalior, India.
Jacques RochetteHEMATIM Unit 4666, Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, Amiens, France.
Perundurai S DhandapanyCentre for Cardiovascular Biology and Disease, Institute for Stem Cell Science and Regenerative Medicine, Bangalore, India.
Pramod Kumar TiwariCentre for Genomics, Molecular & Human Genetics, Jiwaji University, Gwalior, India.
Rabbind Singh AmrathlalCentre for Genomics, Molecular & Human Genetics, Jiwaji University, Gwalior, India.
Lakshmibai National Institute of Physical Education · INInstitute for Stem Cell Biology and Regenerative Medicine · IN

Funding

DBT-Wellcome Trust India Alliance IA/I/16/1/502367
6 · The paper itself

Abstract

backgroundAssociations of genetic variants within certain fibril-forming genes have previously been observed with anterior cruciate ligament (ACL) injuries. Evidence suggests a significant role of angiogenesis-associated cytokines in remodeling the ligament fibril matrix after mechanical loading and maintaining structural and functional integrity of the ligament. Functional polymorphisms within the vascular endothelial growth factor A (VEGFA) gene have emerged as plausible candidates owing to their role in the regulation of angiogenic responses. HYPOTHESIS: VEGFA promoter polymorphisms rs699947 and rs35569394 are associated with ACL injury risk among athletes. STUDY

designCross-sectional study; Level of evidence, 3.

methodsA total of 90 Indian athletes with radiologically confirmed or surgically proven isolated ACL tears and 76 matched-control athletes were selected for the present cross-sectional genetic association study. Oral mouthwash samples were collected from all the case and control athletes and genotyped for VEGFA rs699947 and rs35569394 using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

resultsThe A allele (rs699947) was significantly overrepresented in the ACL group (C vs A allele: odds ratio [OR], 1.68 [95% CI, 1.08-2.60];

conclusionThis is the first study to investigate the association of VEGFA promoter polymorphisms in ACL tears among Indian athletes. Increased frequencies of the A allele (rs699947) and I allele (rs35569394) were observed in the ACL group. These results suggest that sequence variants in the VEGF gene are associated with ACL injury risk among athletes. Further research with long-term follow-ups measuring VEGF expression levels during recovery is warranted to establish its role in ACL injuries and healing.

Indexed as

ACLathletesgenotypinghaplotypepromoter polymorphismsVEGFA

Identifiers

PMID33344666
PMCPMC7731703
OpenAlexW3111521032

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.