Evidence map›Paper›PMID 33344639›Full record

ArticleBioMed research international2020

Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish.

Ping-Hsun Lu, Hsun-Yao Lee, Yan-Liang Liou, Sheng-Fen Tung, Ko-Li Kuo, Yau-Hung Chen

Abstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ping-Hsun LuDepartment of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Rd., Shin-Tien, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0002-0254-6811
Hsun-Yao LeeDepartment of Chemistry, Tamkang University, No. 151, Ying-Chuan Road, Tamsui, New Taipei City 251, Taiwan.
Yan-Liang LiouDepartment of Chemistry, Tamkang University, No. 151, Ying-Chuan Road, Tamsui, New Taipei City 251, Taiwan.
Sheng-Fen TungDepartment of Chemistry, Tamkang University, No. 151, Ying-Chuan Road, Tamsui, New Taipei City 251, Taiwan.
Ko-Li KuoDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289, Jianguo Rd., Shin-Tien, New Taipei City, Taiwan.
Yau-Hung ChenDepartment of Chemistry, Tamkang University, No. 151, Ying-Chuan Road, Tamsui, New Taipei City 251, Taiwan.ORCID https://orcid.org/0000-0003-4436-7464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zhibai Dihuang Wan (ZDW) is an eight-herbal formula of traditional Chinese medicine. Clinically, it regulated immune activity and was used to treat diabetes and renal disease. In this study, we aimed to explore the nephroprotective effect of ZDW in an aristolochic acid- (AA-) intoxicated zebrafish model. We used a green fluorescent kidney transgenic zebrafish to evaluate the nephroprotective effects of ZDW by recording subtle changes in the kidney. Our results demonstrated that ZDW treatment can attenuate AA-induced kidney malformations (60% for AA-treated, 47% for pretreatment with ZDW, and 17% for cotreatment ZDW with AA,

Indexed as

AnimalsAnimals, Genetically ModifiedAristolochic AcidsDrugs, Chinese HerbalGene Expression ProfilingGreen Fluorescent ProteinsImmune SystemKidneyKidney DiseasesMedicine, Chinese TraditionalPhenotypeProtective AgentsRenal InsufficiencySodium-Potassium-Exchanging ATPaseZebrafisharistolochic acid IAristolochic AcidsDrugs, Chinese HerbalGreen Fluorescent ProteinsProtective AgentsSodium-Potassium-Exchanging ATPasezhibai dihuang

Identifiers

PMID33344639
PMCPMC7725560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.