Evidence map›Paper›PMID 33344634›Full record

ArticleBioMed research international2020

Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression.

Chen Zhang, Kunhou Yao, Junjie Zhang, Chenyu Wang, Chaoyang Wang, Changjiang Qin

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. The Relationship betweenMedicina (Kaunas, Lithuania) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chen ZhangFirst Department of Oncology, Xinxiang Central Hospital, Xinxiang, 453000 Henan, China.ORCID https://orcid.org/0000-0003-4776-0165
Kunhou YaoDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000 Henan, China.
Junjie ZhangDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000 Henan, China.
Chenyu WangDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000 Henan, China.
Chaoyang WangDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000 Henan, China.
Changjiang QinDepartment of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000 Henan, China.ORCID https://orcid.org/0000-0001-8924-9061
Henan University Huaihe Hospital and Huaihe Clinical Institute · CNXinxiang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence suggested that lncRNA MALAT1 plays critical roles in the commencement and progression of malignant cancers. Nevertheless, the function of MALAT1 in colorectal cancer (CRC) remains largely unknown. In the present study, we reported that MALAT1 expression is significantly upregulated in CRC and correlated with advanced TNM stage, lymph node metastasis, and worse prognosis in patients. Functional assays revealed that MALAT1 knockdown reduced CRC cell growth and invasion abilities

Indexed as

AgedBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationColorectal NeoplasmsComputational BiologyDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedNeoplasm Invasivenessrab GTP-Binding ProteinsBiomarkers, TumorMALAT1 long non-coding RNA, humanMicroRNAsMIRN508 microRNA, humanRab14 protein, humanrab GTP-Binding ProteinsRNA, Long Noncoding

Identifiers

PMID33344634
PMCPMC7732393
OpenAlexW3110530940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.