Evidence map›Paper›PMID 33344437›Full record

ReviewFrontiers in bioengineering and biotechnology2020

Biosynthesis of Fatty Alcohols in Engineered Microbial Cell Factories: Advances and Limitations.

Anagha Krishnan, Bonnie A McNeil, David T Stuart

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Engineering robustSynthetic and systems biotechnology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Enzymatic reactions towards aldehydes: An overview.Flavour and fragrance journal · 2023
    Review
  9. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Spatial-temporal regulation of fatty alcohol biosynthesis in yeast.Biotechnology for biofuels and bioproducts · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Microbial pathways for advanced biofuel production.Biochemical Society transactions · 2022
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anagha KrishnanDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Bonnie A McNeilDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
David T StuartDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concerns about climate change and environmental destruction have led to interest in technologies that can replace fossil fuels and petrochemicals with compounds derived from sustainable sources that have lower environmental impact. Fatty alcohols produced by chemical synthesis from ethylene or by chemical conversion of plant oils have a large range of industrial applications. These chemicals can be synthesized through biological routes but their free forms are produced in trace amounts naturally. This review focuses on how genetic engineering of endogenous fatty acid metabolism and heterologous expression of fatty alcohol producing enzymes have come together resulting in the current state of the field for production of fatty alcohols by microbial cell factories. We provide an overview of endogenous fatty acid synthesis, enzymatic methods of conversion to fatty alcohols and review the research to date on microbial fatty alcohol production. The primary focus is on work performed in the model microorganisms,

Indexed as

carboxylic acid reductasecyanobacteriaE. colifatty alcoholfatty alcohol reductasemetabolic engineeringS. cerevisiaeyeast

Identifiers

PMID33344437
PMCPMC7744569
OpenAlexW3108670258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.