ArticleFrontiers in bioengineering and biotechnology2020
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 34 citations in OpenAlex.
- A novel pulsed field ablation system using linear and spiral ablation catheters can create large and durable endocardial and epicardial ventricular lesions in vivo.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Feasibility study of intravascular pulsed electric field ablation for the treatment of cardiac arrhythmias.Frontiers in physiology · 2025Article
- Pulsed electric field ablation process-a study of the effect of different shapes (materials) of metal stents on the ablation effect.Frontiers in cardiovascular medicine · 2025Article
- Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias.Journal of cardiovascular development and disease · 2024Review
- A New Hope for the Treatment of Atrial Fibrillation: Application of Pulsed-Field Ablation Technology.Journal of cardiovascular development and disease · 2024Review
- Epicardial pulsed-field ablation-impact of electric field and heat distribution induced by coronary metallic stents.Frontiers in cardiovascular medicine · 2024Article
- Pulsed electric field performance calculator tool based on anFrontiers in physiology · 2024Article
- Pearls and Pitfalls of Pulsed Field Ablation.Korean circulation journal · 2023Review
- Potential Application of Pulsed Field Ablation in Ventricular Arrhythmias.Medicina (Kaunas, Lithuania) · 2023Review
- Comparative Analysis of Temperature Rise between Convective Heat Transfer Method and Computational Fluid Dynamics Method in an Anatomy-Based Left Atrium Model during Pulsed Field Ablation: A Computational Study.Journal of cardiovascular development and disease · 2023Article
- Article
- Pulsed-Field Ablation Using a Novel Ablation-Mapping Integrated System for Pulmonary Vein Isolation-A Preliminary Animal Study.Journal of cardiovascular development and disease · 2022Article
- A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber.Scientific reports · 2022Article
- Catheter ablation induced phrenic nerve palsy by pulsed field ablation-completely impossible? A case series.European heart journal. Case reports · 2022Article
- HumanFrontiers in physiology · 2022Article
- Ablation Modalities for Therapeutic Intervention in Arrhythmia-Related Cardiovascular Disease: Focus on Electroporation.Journal of clinical medicine · 2021Review
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Authors and funding
13 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.
methodsWe employed 6 female swine - weight 53.75 ± 4.77 kg - in this study. With fluoroscopic and electroanatomical mapping assistance, we performed ECG-gated AC-PFA in the following settings: in the left atrium with a decapolar loop catheter with electrodes connected in bipolar fashion; across the interventricular septum applying energy between the distal electrodes of two tip catheters. After procedure and 4-week follow-up, the animals were euthanized, and the hearts were inspected for tissue changes and characterized. We perform finite element method simulation of our AC-PFA scenarios to corroborate our method and better interpret our findings.
resultsWe applied square, 50% duty cycle, AC bursts of 100 μs duration, 100 kHz internal frequency, 900 V for 60 pulses in the atrium and 1500 V for 120 pulses in the septum. The inter-burst interval was determined by the native heart rhythm - 69 ± 9 bpm. Acute changes in the atrial and ventricular electrograms were immediately visible at the sites of AC-PFA - signals were elongated and reduced in amplitude (
conclusionWe proved that our method and technology of AC-PFA is feasible and safe for atrial and ventricular myocardial ablation, supporting their systematic investigation into effectiveness evaluation for the treatment of cardiac arrhythmia. Further optimization, with energy titration or longer follow-up, is required for a robust atrial and ventricular AC-PFA.
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