ReviewFrontiers in pediatrics2020
Pediatric Inflammatory Multisystem Syndrome and Rheumatic Diseases During SARS-CoV-2 Pandemic.
Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04846010 (Treating Sequalae Caused by Post-acute Sequelae of SARS), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characteristics of Children With Kawasaki Disease-Like Signs in COVID-19 Pandemic: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Detection of serum composition in pediatric inflammatory multisystem syndrome associated with SARS-CoV-2 and the response for the treatment by FTIR.Scientific reports · 2025Article
- The High Levels of Soluble Receptors for Tumor Necrosis Factor and Heart Injury in Children with the Pediatric Inflammatory Multisystem Syndrome Associated with Coronavirus Infection: Is This Just a Coincidence? A Proof-of-Concept Study.International journal of molecular sciences · 2025Article
- Multisystem Inflammatory Syndrome in Children Admitted to a Tertiary Pediatric Intensive Care Unit.Journal of pediatric intensive care · 2023Article
- Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19.Future virology · 2022Review
- COVID-19 and PIMS-Two Different Entities, but the Same Trigger.Children (Basel, Switzerland) · 2022Article
- Clinical characteristics and mortality risk factors in patients aged less than 18 years with COVID-19 in Mexico and Mexico City.Anales de pediatria · 2022Article
- [Clinical characteristics and mortality risk factors in patients aged less than 18 years with COVID-19 in Mexico and Mexico City].Anales de pediatria (Barcelona, Spain : 2003) · 2022Article
- Cardiac Screening: An Important Diagnostic Tool in the Early Identification of High-Risk Children with Post-COVID-19 Multisystem Inflammatory Syndrome in Children.The Malaysian journal of medical sciences : MJMS · 2022Article
- Cellular, Antibody and Cytokine Pathways in Children with Acute SARS-CoV-2 Infection and MIS-C-Can We Match the Puzzle?Antibodies (Basel, Switzerland) · 2022Review
- MIS-C Case Presented with Acute Appendicitis and Successfully Treated by Plasmapheresis.Turkish archives of pediatrics · 2022Article
- Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children.Journal of endocrinological investigation · 2022Article
- COVID-19: potential therapeutics for pediatric patients.Pharmacological reports : PR · 2021Review
- Clinical features and outcomes of 76 patients with COVID-19-related multi-system inflammatory syndrome in children.Clinical rheumatology · 2021Article
- COVID-19 infection in patients with severe aplastic anaemia.British journal of haematology · 2021Article
- Polyclonal expansion of TCR Vbeta 21.3Science immunology · 2021Article
- Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.Physiological research · 2021Review
- PIMS-TS, the New Paediatric Systemic Inflammatory Disease Related to Previous Exposure to SARS-CoV-2 Infection-"Rheumatic Fever" of the 21st Century?International journal of molecular sciences · 2021Review
- COVID-19 and Dentistry in 72 Questions: An Overview of the Literature.Journal of clinical medicine · 2021Review
- Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared to have a milder clinical course in children compared to adults. As severe forms of COVID-19 in adults included an aberrant systemic immune response, children with chronic systemic inflammatory diseases were cautiously followed. No evidence for a specific susceptibility was identified in this pediatric population. European and US Pediatricians started to notice cases of myocarditis, sharing some features with toxic shock syndrome, Kawasaki disease, and macrophage activation syndrome in otherwise healthy patients. Multisystem Inflammatory Syndrome in Children (MIS-C) and Pediatric Inflammatory Multisystem Syndrome (PIMS) have designated this new entity in the US and Europe, respectively. The spectrum of severity ranged from standard hospitalization to pediatric intensive care unit management. Most patients had a clinical history of exposure to COVID-19 patients and/or SARS-COV2 biological diagnosis. Clinical presentations include fever, cardiac involvement, gastro-intestinal symptoms, mucocutaneous manifestations, hematological features, or other organ dysfunctions. The temporal association between the pandemic peaks and outbreaks of PIMS seems to be in favor of a post-infectious, immune-mediated mechanism. Thus, SARS-CoV2 can rarely be associated with severe systemic inflammatory manifestations in previously healthy children differently from adults highlighting the specific need for COVID-19 research in the pediatric population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.