Evidence map›Paper›PMID 33344322›Full record

ArticleAutopsy & case reports2020

Two cases of rare HHV8-driven intravascular lymphoma with synchronous Kaposi sarcoma, both diagnosed at autopsy in renal transplant recipients.

Paida Gwiti, Megan Jenkins, Judit Sutak, Zsombor Melegh

Abstract readCase Reports
In one paragraph

Article in Autopsy & case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paida GwitiPeterborough City Hospital, Department of Cellular Pathology, Peterborough, UK.ORCID 0000-0002-2486-5194
Megan JenkinsRoyal Liverpool University Hospital, Forensic Pathology Unit, Liverpool, UK.ORCID 0000-0002-5106-8676
Judit SutakDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.ORCID 0000-0003-3777-4061
Zsombor MeleghDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.ORCID 0000-0001-7605-5719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the first report of two rare yet remarkably similar autopsy cases of Kaposi sarcoma (KS) and intravascular human herpesvirus 8 (HHV8) positive lymphoproliferative disorder in renal transplant patients. It is well established that HHV8 infection causes Kaposi sarcoma (KS). More recently, it is recognized that HHV8 is also related to several lymphoproliferative conditions. These are poorly characterized and often difficult to diagnose. In both cases described herein, the diagnoses of multifocal hepatic KS and intravascular HHV8 positive (EBV negative) systemic diffuse large B-cell lymphoma, NOS were made at autopsy. Given the findings we describe in cases with fatal outcomes, we discuss the implications of HHV8 screening in solid allograft recipients.

Indexed as

Herpesvirus 8, HumanSarcoma, Kaposi, Autopsy, Transplantation, Lymphoproliferative disorder, Intravascular lymphoma

Identifiers

PMID33344322
PMCPMC7707703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.