ArticleFrontiers in oncology2020
Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function.
Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Iron diminishes immunosuppressive macrophages and enhances anti-PD-1 immunotherapy in breast cancer models.Journal of experimental & clinical cancer research : CR · 2026Article
- Iron and the immune system.Nature reviews. Immunology · 2025Review
- Downregulation of PDIA4 inhibits proliferation and migration in human oral squamous cell carcinoma.Hereditas · 2025Article
- Iron overload-induced ferroptosis in CD8BMC medicine · 2025Article
- TIM-3 ameliorates host responses to Salmonella infection by controlling iron driven CD4EBioMedicine · 2025Article
- Effects of Balanced Supplementation with Multiple Trace Elements on Oxidative Stress, Inflammation, and Immune Function in High-Fat Diet-Induced Rats.International journal of preventive medicine · 2025Article
- The Impact of Iron on Cancer-Related Immune Functions in Oncology: Molecular Mechanisms and Clinical Evidence.Cancers · 2024Review
- The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs.Journal of animal science and biotechnology · 2024Article
- Microbial harmony in female reproductive health: exploring the impact of intestinal flora on ovarian function and disease pathogenesis.American journal of translational research · 2024Review
- Lipocalin-2: A Nurturer of Tumor Progression and a Novel Candidate for Targeted Cancer Therapy.Cancers · 2023Review
- Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia.African health sciences · 2023Article
- Prognostic and therapeutic implications of iron-related cell death pathways in acute myeloid leukemia.Frontiers in oncology · 2023Article
- Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma.Frontiers in cell and developmental biology · 2023Article
- Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy.Biomolecules · 2022Article
- Ferric Ammonium Citrate Upregulates PD-L1 Expression through Generation of Reactive Oxygen Species.Journal of immunology research · 2022Article
- The Iron Curtain: Macrophages at the Interface of Systemic and Microenvironmental Iron Metabolism and Immune Response in Cancer.Frontiers in immunology · 2021Review
- Regulation of Th1 T Cell Differentiation by IronFrontiers in immunology · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Iron is both, an essential compound for many metabolic processes, and iron deficiency can impact on the proliferation of cells including lymphocytes but also tumor cells. On the other hand, excess iron-catalyzed radical formation can induce cellular toxicity which has been previously demonstrated for T cells in hereditary iron overload. Despite these interconnections, little is known on the effects of clinically approved intravenous iron supplements for curing cancer-related anemia, on T cell differentiation, tumor proliferation, anti-tumor T cell responses and, of clinical importance, on efficacy of cancer immunotherapies. Herein, we analyzed the effects of intravenous iron supplementation on T cell function and on the effectiveness of anti-cancer chemotherapy with IL-2/doxorubicin or immunotherapy with checkpoint-inhibitor anti-PD-L1 in C57Bl/6N female mice with implanted E0771 mammary carcinomas. We found that iron application resulted to an increased availability of iron in the tumor microenvironment and stimulation of tumor growth. In parallel, iron application inhibited the activation, expansion and survival of cytotoxic CD8
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.