Evidence map›Paper›PMID 33344118›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Bimodal Imaging-Visible Nanomedicine Integrating CXCR4 and VEGFa Genes Directs Synergistic Reendothelialization of Endothelial Progenitor Cells.

Bingbo Yu, Bing Dong, Jiang He, Hui Huang, Jinsheng Huang, Yong Wang, Jianwen Liang, Jianning Zhang, Yumin Qiu, Jun Shen and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bingbo YuDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Bing DongDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Jiang HeDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Hui HuangDepartment of Cardiovascular The Eighth Affiliated Hospital of Sun Yat-sen University Shenzhen 518000 China.
Jinsheng HuangPCFM Lab of Ministry of Education School of Material Science and Engineering Sun Yat-sen University Guangzhou 510275 China.
Yong WangPCFM Lab of Ministry of Education School of Material Science and Engineering Sun Yat-sen University Guangzhou 510275 China.
Jianwen LiangDepartment of Cardiovascular The Eighth Affiliated Hospital of Sun Yat-sen University Shenzhen 518000 China.
Jianning ZhangDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Yumin QiuDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Jun ShenDepartment of Radiology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou 510120 China.
Xintao ShuaiDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.ORCID https://orcid.org/0000-0003-4271-0310
Jun TaoDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.
Wenhao XiaDepartment of Hypertension and Vascular Disease The First Affiliated Hospital of Sun Yat-sen University National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Key Laboratory on Assisted Circulation Ministry of Health Guangzhou 510080 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major challenge to treat vascular endothelial injury is the restoration of endothelium integrity in which endothelial progenitor cells (EPCs) plays a central role. Transplantation of EPCs as a promising therapeutic means is subject to two interrelated processes, homing and differentiation of EPCs in vivo, and thus a lack of either one may greatly affect the outcome of EPC-based therapy. Herein, a polymeric nanocarrier is applied for the codelivery of CXCR4 and VEGFa genes to simultaneously promote the migration and differentiation of EPCs. Moreover, MRI T

Indexed as

bimodal imagingcardiovascular diseaseendothelial progenitor cellsnanomedicinevascular endothelial injury repairing

Identifiers

PMID33344118
PMCPMC7740091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.