Evidence map›Paper›PMID 33344000›Full record

ArticleACS catalysis2020

Catalytic Roles of Coenzyme Pyridoxal-5'-phosphate (PLP) in PLP-dependent Enzymes: Reaction Pathway for Methionine-γ-lyase-catalyzed L-methionine Depletion.

Zhe Li, Yunsong Zhao, Huifang Zhou, Hai-Bin Luo, Chang-Guo Zhan

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Vitamin BCommunications biology · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Molecular Structure of Phosphoserine Aminotransferase fromInternational journal of molecular sciences · 2023
    Article
  10. Structural Basis of the Inhibition of L-Methionine γ-Lyase fromInternational journal of molecular sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Zhe LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China.
Yunsong ZhaoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China.
Huifang ZhouSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China.
Hai-Bin LuoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P.R. China.ORCID 0000-0002-2163-0509
Chang-Guo ZhanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536.ORCID 0000-0002-4128-7269
Sun Yat-sen University · CNUniversity of Kentucky · US

Funding

Phosphodiesterase-2 and Mood Disorders: Target Validation and Drug DiscoveryRC1MH088480 · NIMH · WEST VIRGINIA UNIVERSITY · PI O'DONNELL, JAMES M, ZHAN, CHANG-GUO · 2009 to 2010
$952k
NIMH NIH HHS RC1 MH088480
6 · The paper itself

Abstract

Pyridoxal-5'-phosphate (PLP), the active form of vitamin B

Indexed as

Catalytic mechanismL-methionine depletionMethionine-γ-lyasePyridoxal-5′-phosphateQM/MM calculation

Identifiers

PMID33344000
PMCPMC7745990
OpenAlexW2999799059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.