ArticleTurkish journal of obstetrics and gynecology2020
The relationship between isolated pes equinovarus and aneuploidies and perinatal outcomes: Results of a tertiary center.
Article in Turkish journal of obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Prenatal diagnosis of congenital talipes equinovarus: favorable outcome is highly dependent on the absence of associated anomalies.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Prenatal diagnosis of isolated bilateral clubfoot: Is amniocentesis indicated?Acta obstetricia et gynecologica Scandinavica · 2024Observational
- Article
- Prenatal Diagnosis of Clubfoot: Where Are We Now? Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
objectiveCongenital pes equinovarus (PEV) is the most common congenital deformity of the foot, characterized by plantar flexion with a frequency of 0.2-0.3%. It can be diagnosed from the 12 MATERIALS AND
methodsThis was a retrospective cohort study conducted between March 2015-March 2020. Women who presented for fetal anomaly screening or were referred due to any suspected fetal anomaly were subjected to detailed fetal anomaly scans and checked for the presence of PEV. Karyotype analysis was discussed for patients with PEV. Pregnancy termination was recommended for those with chromosomal/life-threatening anomalies. The diagnosis was confirmed by postnatal examination/autopsy. Postnatal diagnosis was accepted as false-positive in those with no PEV.
resultsOne-hundred thirty-eight patients were found to have PEV, 41 (29.7%) of which were isolated. In the isolated group, the false-positive rate in the first trimester was significantly higher compared with the second trimester, 50%/15.3%, respectively (p<0.05). Chromosomal anomalies were detected in 2 (4.8%) patients in the isolated group. Termination was performed to 1 (2.4%) patients due to trisomy 21. In the non-isolated group, chromosomal anomalies were detected in 13 (13.4%) patients, and termination was recommended. Termination was also recommended to 18 (18.5%) patients due to anomalies incompatible with life. In the postnatal evaluation, the surgical treatment rate in the isolated/non-isolated groups was 6%/39.7% (p<0.05).
conclusionWhen PEV is diagnosed, detailed fetal anomaly screening must be performed, patients should be informed about the chromosomal anomaly risk. High false-positive rates in the first trimester should be kept in mind for diagnosis. Karyotype analysis should be recommended also to isolated cases. It should be remembered that some neuromuscular/skeletal system anomalies may occur for the first time in the postnatal period in isolated cases.
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