Evidence map›Paper›PMID 33343920›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

CD8

I S Brorson, A M Eriksson, I S Leikfoss, V Vitelli, E G Celius, T Lüders, T Berge, H F Harbo, H Nilsen, S D Bos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

I S BrorsonInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
A M ErikssonInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
I S LeikfossInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
V VitelliOslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway.
E G CeliusInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-9127-6488
T LüdersDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Oslo, Norway.
T BergeDepartment of Mechanical, Electronics and Chemical Engineering, Oslo Metropolitan University, Oslo, Norway.
H F HarboInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
H NilsenDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Oslo, Norway.
S D BosInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-2975-7520
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS.

objectivesAnalysis of the gene expression profiles of circulating CD8

methodsRNA from purified CD8

resultsWe identified 36 genes with significant differential gene expression in MS patients. Four genes reached at least 2-fold differences in expression. The majority of differentially expressed genes was higher expressed in MS patients. Genes associated to MS in GWAS showed enrichment amongst the differentially expressed genes. We did not identify enrichment of specific pathways amongst the differentially expressed genes in MS patients.

conclusionsCD8

Indexed as

autoimmunitygene expressionMultiple sclerosisneurologyRNAT-Lymphocytes

Identifiers

PMID33343920
PMCPMC7731718
OpenAlexW3111513967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.