Evidence map›Paper›PMID 33343906›Full record

ArticleMaterials horizons2020

Augmenting T-cell responses to tumors by

Mohammad Mahdi Hasani-Sadrabadi, Fatemeh S Majedi, Matthew L Miller, Timothy J Thauland, Louis-S Bouchard, Song Li, Manish J Butte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials horizons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Mahdi Hasani-SadrabadiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Fatemeh S MajediDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Matthew L MillerMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Timothy J ThaulandDepartment of Pediatrics, Division of Immunology, Allergy, and Rheumatology, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Louis-S BouchardDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Song LiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095 USA.
Manish J ButteMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA, 90095 USA.

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Influences of nanomechanical forces on T cellsR01GM110482 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTTE, MANISH J · 2014 to 2018
$1.6M
Therapeutic microneedles for localized treatment of periodontal tissueR56DE029157 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2019
$286k
NIDCR NIH HHS R56 DE029157NIGMS NIH HHS R01 GM110482NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

Recent innovations in immunoregulatory treatments have demonstrated both the impressive potential and vital role of T cells in fighting cancer. These treatments come at a cost, with systemic side effects including life-threatening autoimmunity and immune dysregulation the norm. Here, we developed an approach to locally synthesize immune therapies and in this way, avoid systemic toxicity. Rather than just encapsulating cytokines, we endowed our nanoparticles with transcriptional and translational machinery to

Identifiers

PMID33343906
PMCPMC7748250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.