ArticlePulmonary circulation
Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
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Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mechanistic studies of molecular networks associated with pulmonary hypertension explored by combined transcriptome analysis of Project-methylation.Clinical epigenetics · 2026Article
- Treatment Response and Survival in Methamphetamine-Associated Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2025Article
- Identification and Validation of Potential Diagnostic Biomarkers for Pulmonary Arterial Hypertension Based on Gene Expression Profiling.Pulmonary circulation · 2025Article
- Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension.ERJ open research · 2025Article
- Identification of a PANoptosis-related gene signature reveals therapeutic potential of SFRP2 in pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025Article
- Article
- Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension.Respiratory research · 2024Article
- PI3K p85α/HIF-1α accelerates the development of pulmonary arterial hypertension by regulating fatty acid uptake and mitophagy.Molecular medicine (Cambridge, Mass.) · 2024Article
- Exploring the diagnostic and immune infiltration roles of disulfidptosis related genes in pulmonary hypertension.Respiratory research · 2024Article
- Transcriptome analyses reveal common immune system dysregulation in PAH patients andPulmonary circulation · 2024Article
- Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.Circulation research · 2024Article
- Metabolic and Proteomic Divergence Is Present in Circulating Monocytes and Tissue-Resident Macrophages from Berkeley Sickle Cell Anemia and β-Thalassemia Mice.Journal of proteome research · 2023Article
- Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension.BMC pulmonary medicine · 2023Article
- Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and CaPhysiological reviews · 2023Review
- Decoding the mechanism of hypertension through multiomics profiling.Journal of human hypertension · 2023Review
- Identification of diagnostic biomarkers for idiopathic pulmonary hypertension with metabolic syndrome by bioinformatics and machine learning.Scientific reports · 2023Article
- Comprehensive analyses of m6A RNA methylation patterns and related immune microenvironment in idiopathic pulmonary arterial hypertension.Frontiers in genetics · 2023Article
- The identification and verification of hub genes associated with pulmonary arterial hypertension using weighted gene co-expression network analysis.BMC pulmonary medicine · 2022Article
- miR-155-5p regulates hypoxia-induced pulmonary artery smooth muscle cell function by targeting PYGL.Bioengineered · 2022Article
- Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.Nature communications · 2021Article
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Authors and funding
20 authors.
Casey E RomanoskiDepartment of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Xinshuai QiDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Shreya SangamDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Rebecca R VanderpoolDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Robert S StearmanDepartment of Medicine, Indiana University, Indianapolis, IN, USA.
Austin ConklinDepartment of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Manuel Gonzalez-GarayDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Franz RischardDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Ramon J AyonDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Jian WangDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Tatum SimonsonDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Aleksandra BabichevaDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yinan ShiDepartment of Medicine, Indiana University, Indianapolis, IN, USA.
Haiyang TangDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Ayako MakinoDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Yogendra KanthiDivision of Intramural Research National Heart, Lung and Blood Institute Bethesda, Maryland, USA.
Mark W GeraciDepartment of Medicine, Indiana University, Indianapolis, IN, USA.
Joe G N GarciaDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Jason X-J YuanDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Ankit A DesaiDepartment of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Funding
PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5MPulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MIon Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6MNovel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8MPathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4MPurinergic regulation of Innate Immunity to promote Venous HomeostasisR01HL150392 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PINSKY, DAVID J. · 2020 to 2024
$2.2MMechanisms of ERG in Endothelial ActivationR01HL147187 · NHLBI · UNIVERSITY OF ARIZONA · PI ROMANOSKI, CASEY E · 2019 to 2023
$1.9MPhenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5MCD39 in Vein Graft ArterializationK08HL131993 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KANTHI, YOGENDRA · 2016 to 2020
$837kSystems Genetic Analysis of Atherogenic Transcriptional Regulation in Human CellsR00HL123485 · NHLBI · UNIVERSITY OF ARIZONA · PI ROMANOSKI, CASEY E · 2016 to 2018
$740kNHLBI NIH HHS K08 HL131993NHLBI NIH HHS R00 HL123485NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL147187NHLBI NIH HHS R01 HL150392NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R35 HL135807NHLBI NIH HHS T32 HL007249NHLBI NIH HHS U01 HL125208
Abstract
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
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PBMCpulmonary arterial hypertensionRNAseqtranscriptome profiling
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