ArticleComputational and structural biotechnology journal2021
Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome.
Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular Basis of High-Blood-Pressure-Enhanced and High-Fever-Temperature-Weakened Receptor-Binding Domain/Peptidase Domain Binding: A Molecular Dynamics Simulation Study.International journal of molecular sciences · 2025Article
- Article
- Parabacteroides distasonis regulates the infectivity and pathogenicity of SVCV at different water temperatures.Microbiome · 2024Article
- COVID-19 and Cancer Diseases-The Potential ofInternational journal of molecular sciences · 2023Review
- Therapeutic hyperthermia for the treatment of infection-a narrative review.Frontiers in physiology · 2023Review
- Understanding the role of water on temperature-dependent structural modifications of SARS CoV-2 main protease binding sites.Journal of molecular liquids · 2022Article
- Fever as an evolutionary agent to select immune complexes interfaces.Immunogenetics · 2022Article
- A Temperature-Sensitive Recombinant of Avian Coronavirus Infectious Bronchitis Virus Provides Complete Protection against Homologous Challenge.Journal of virology · 2022Article
- The natural thermal sensitivity of SARS-CoV-2.Infectious medicine · 2022Article
- Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2.Chemical reviews · 2022Review
- Do compromised mitochondria aggravate severity and fatality by SARS-CoV-2?Current medical research and opinion · 2022Article
- Review
- The Molecular Basis of the Effect of Temperature on the Structure and Function of SARS-CoV-2 Spike Protein.Frontiers in molecular biosciences · 2022Article
- Modeling of the thermal properties of SARS-CoV-2 S-protein.Frontiers in molecular biosciences · 2022Article
- Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2.Computational and structural biotechnology journal · 2022Article
- Design and Manufacturing Optoelectronic Sensors for the Measurement of Refractive Index Changes under Unknown Polarization State.Sensors (Basel, Switzerland) · 2021Article
- The impact of coronavirus SARS-CoV-2 (COVID-19) in water: potential risks.Environmental science and pollution research international · 2021Review
- Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.The Journal of biological chemistry · 2021Article
- Emerging role of air pollution and meteorological parameters in COVID-19.Journal of evidence-based medicine · 2021Review
- Comparison of the binding characteristics of SARS-CoV and SARS-CoV-2 RBDs to ACE2 at different temperatures by MD simulations.Briefings in bioinformatics · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SARS-CoV-2 virus and its homolog SARS-CoV penetrate human cells by binding of viral spike protein and human angiotensin converting enzyme II (ACE2). SARS-CoV causes high fever in almost all patients, while SARS-CoV-2 does not. Moreover, analysis of the clinical data revealed that the higher body temperature is a protective factor in COVID-19 patients, making us to hypothesize a temperature-dependent binding affinity of SARS-CoV-2 to human ACE2 receptor. In this study, our molecular dynamics simulation and protein surface plasmon resonance cohesively proved the SARS-CoV-2-ACE2 binding was less affinitive and stable under 40 °C (~18 nM) than the optimum temperature 37 °C (6.2 nM), while SARS-CoV-ACE2 binding was not (6.4 nM vs. 8.5 nM), which evidenced the temperature-dependent affinity and explained that higher temperature is related to better clinical outcome. The decreased infection at higher temperature was also validated by pseudovirus entry assay using Vero and Caco-2 cells. We also demonstrated the structural basis of the distinct temperature-dependence of the two coronaviruses. Furthermore, the meta-analysis revealed a milder inflammatory response happened in the early stage of COVID-19, which explained the low fever tendency of COVID-19 and indicated the co-evolution of the viral protein structure and the inflammatory response. The temperature dependence of the binding affinity also indicated that higher body temperature at early stages might be beneficial to the COVID-19 patients.
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