Evidence map›Paper›PMID 33343832›Full record

ArticleNano research2019

Critical Size Limit of Biodegradable Nanoparticles for Enhanced Lymph Node Trafficking and Paracortex Penetration.

Gregory P Howard, Garima Verma, Xiyu Ke, Winter M Thayer, Timothy Hamerly, Victoria K Baxter, John E Lee, Rhoel R Dinglasan, Hai-Quan Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 116 citations in OpenAlex.

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  19. Synthetic organic materials for targeting immunotherapies to lymph nodes.Chemistry of materials : a publication of the American Chemical Society · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gregory P HowardDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, USA.
Garima VermaW. Harry Feinstone Department of Molecular Microbiology & Immunology, and the Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Xiyu KeInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, USA.
Winter M ThayerJohns Hopkins School of Nursing, Baltimore, USA.
Timothy HamerlyEmerging Pathogens Institute, Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, USA.
Victoria K BaxterW. Harry Feinstone Department of Molecular Microbiology & Immunology, and the Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
John E LeeDepartment of Biomedical Engineering, Yale University, New Haven, USA.
Rhoel R DinglasanW. Harry Feinstone Department of Molecular Microbiology & Immunology, and the Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Hai-Quan MaoDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USUniversity of Florida · USYale University · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
A biodegradable nano-microparticle prime-boost vaccine strategyR01AI114609 · NIAID · UNIVERSITY OF FLORIDA · PI DINGLASAN, RHOEL DAVID RAMOS, MAO, HAI-QUAN · 2015 to 2019
$1.6M
NIAID NIH HHS R01 AI114609NIH HHS T32 OD011089
6 · The paper itself

Abstract

Lymph node (LN) targeting through interstitial drainage of nanoparticles (NPs) is an attractive strategy to stimulate a potent immune response, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective "size gate" for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-

Indexed as

Antigen presenting cellsBiodegradable nanoparticleIn vivo imagingLymph node traffickingNanoparticle sizeVaccine delivery

Identifiers

PMID33343832
PMCPMC7747954
OpenAlexW2911310494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.