Evidence map›Paper›PMID 33343684›Full record

ReviewFuture virology2020

Nanoparticle vaccines against respiratory syncytial virus.

Laura M Stephens, Steven M Varga

Open access · greenAbstract readReview
In one paragraph

Review in Future virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura M StephensInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.ORCID https://orcid.org/0000-0002-9724-2748
Steven M VargaInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.ORCID https://orcid.org/0000-0001-7332-4290
University of Iowa · US

Funding

PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Balancing protection versus immunopathology by RSV-specific memory CD8 T cellsR01AI124093 · NIAID · UNIVERSITY OF IOWA · PI VARGA, STEVEN M · 2017 to 2020
$1.6M
NIAID NIH HHS R01 AI124093NIAID NIH HHS T32 AI007485
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of respiratory disease in infants, the elderly and immunocompromised individuals. Despite the global burden, there is no licensed vaccine for RSV. Recent advances in the use of nanoparticle technology have provided new opportunities to address some of the limitations of conventional vaccines. Precise control over particle size and surface properties enhance antigen stability and prolong antigen release. Particle size can also be modified to target specific antigen-presenting cells in order to induce specific types of effector T-cell responses. Numerous nanoparticle-based vaccines are currently being evaluated for RSV including inorganic, polymeric and virus-like particle-based formulations. Here, we review the potential advantages of using different nanoparticle formulations in a vaccine for RSV, and discuss many examples of safe, and effective vaccines currently in both preclinical and clinical stages of testing.

Indexed as

adjuvantlungnanoparticlerespiratory syncytial virusRSVvaccine

Identifiers

PMID33343684
PMCPMC7737143
OpenAlexW3109049349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.