Evidence map›Paper›PMID 33343563›Full record

ArticleFrontiers in immunology2020

Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes.

Xiaolong Liu, Jun Zhao, Ce Shi, Zhiyu Liu, Hongtao Shen, Junlong Dang, Yang Li, Dongguang Yang, Jia Wei, Liqing Kang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Xiaolong LiuCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Jun ZhaoDepartment of Clinical Immunology, Third Hospital of Sun Yat-sen University, Guangzhou, China.
Ce ShiCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Zhiyu LiuCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Hongtao ShenDepartment of Orthopedic Surgery, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Junlong DangDepartment of Clinical Immunology, Third Hospital of Sun Yat-sen University, Guangzhou, China.
Yang LiCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Dongguang YangCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Jia WeiCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Liqing KangInstitute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Jin ZhouDepartment of Hematology, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Fenglin CaoCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
Song Guo ZhengDepartment of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, United States.
Zhenkun WangCentral Laboratory, First Affiliated Hospital, Harbin Medical University, Harbin, China.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNThird Affiliated Hospital of Sun Yat-sen University · CNEast China Normal University · CNThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokine cascades exist in many autoimmune disorders which amplify and sustain the autoimmune process and lead to chronic inflammatory injury to the host tissues. Increasing evidence indicates that chondrocytes can interact with T cells, which may be a crucial event in inflammatory arthritis. To address the reciprocal influences of cartilage-reactive T cells and chondrocytes, we constructed cartilage-reactive T cells by developing a type II collagen-specific chimeric antigen receptor (CII-CAR). An

Indexed as

AdolescentAdultAgedArthritisCartilageCells, CulturedChondrocytesCoculture TechniquesCollagen Type IICytokinesHumansMiddle AgedReceptors, Chimeric AntigenT-LymphocytesYoung AdultCollagen Type IICytokinesReceptors, Chimeric Antigencartilagechimeric antigen receptor T cellcytokine cascadeinflammatory arthritistype II collagen

Identifiers

PMID33343563
PMCPMC7746615
OpenAlexW3108531319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.