Evidence map›Paper›PMID 33343494›Full record

ArticleFrontiers in neurology2020

Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients.

Ovidiu C Andronesi, Katharine Nicholson, Kourosh Jafari-Khouzani, Wolfgang Bogner, Jing Wang, James Chan, Eric A Macklin, Mark Levine-Weinberg, Christopher Breen, Michael A Schwarzschild and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  10. Establishing anAnnals of translational medicine · 2021
    Article
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  13. Glutathione in the Brain.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Ovidiu C AndronesiDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Katharine NicholsonNeurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, United States.
Kourosh Jafari-KhouzaniDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Wolfgang BognerHigh Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Jing WangDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
James ChanBiostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
Eric A MacklinBiostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
Mark Levine-WeinbergNeurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, United States.
Christopher BreenNeurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, United States.
Michael A SchwarzschildMassGeneral Institute for Neurodegenerative Disease, Charlestown, MA, United States.
Merit CudkowiczNeurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, United States.
Bruce R RosenDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Sabrina PaganoniNeurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, United States.
Eva-Maria RataiDepartment of Radiology, A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Massachusetts General Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · USClinical Research Institute · USMedical University of Vienna · ATUnion Hospital · CN

Funding

Development of whole-brain in vivo 2HG imaging for precision medicine in mutant IDH gliomaR01CA211080 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Ovidiu C Andronesi · 2017 to 2026
$5.4M
NCI NIH HHS R01 CA211080
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

amyotrophic lateral sclerosis (ALS)diffusion tensor imaging (DTI)glutathione (GSH)macromolecular fractionmagnetic resonance spectroscopic imaging (MRSI)neurochemistryneurodegenerationT1 relaxation in the rotating frame (T1rho)

Identifiers

PMID33343494
PMCPMC7744722
OpenAlexW3107337931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.