ReviewFrontiers in psychiatry2020
The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression.
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model.Psychophysiology · 2026Pooled it
- Grief-Related Psychopathology from Complicated Grief to DSM-5-TR Prolonged Grief Disorder: A Systematic Review of Biochemical Findings.International journal of molecular sciences · 2025Pooled it
- Suicidal incidence and gender-based discrepancies in prolonged grief disorder: insights from a meta-analysis and systematic review.Frontiers in psychiatry · 2024Pooled it
- Long-term physical and mental health effects of unresolved disaster-related bereavement: evidence from an 8-year propensity score-matched cohort study.European journal of psychotraumatology · 2026Article
- Anxiety and Depression in Women's Cardiovascular Health: Risk Modifiers, Mechanisms and Clinical Implications.Journal of cardiovascular development and disease · 2026Review
- Participants' Evolving Experiences, Hope, and Coping While Enrolled in a Community-Based Bereavement Support Program: A Pre-Post Mixed-Methods Pilot Study.Current oncology (Toronto, Ont.) · 2026Article
- Preliminary Evaluation of the Psychometric Properties of the Ukrainian Traumatic Grief Inventory-Self Report Plus (TGI-SR+).Clinical psychology in Europe · 2026Article
- Prolonged Grief-Related Symptoms Among Young Individuals After Loss of a Parent or Sibling to Cancer: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Navigating Loss in Animal-Assisted Services: Volunteer Experiences and Implications for Programs Following Therapy Dog Death or Retirement.Animals : an open access journal from MDPI · 2026Article
- Depressive symptom networks before and after widowhood in middle-aged and older adults: findings from four prospective cohort studies.European journal of psychotraumatology · 2025Article
- The impact of childhood maltreatment and parental styles on telomere length: the modulatory role of A118G.European journal of psychotraumatology · 2025Article
- Widowhood mortality among married and cohabiting partners: a nationwide study in Finland.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Territories of mourning: Addressing submerged problems of grief through multidisciplinary care.World journal of clinical cases · 2025Article
- Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study.Autism : the international journal of research and practice · 2025Article
- Mourning for Silence: Bereavement and Tinnitus-A Perspective.Journal of clinical medicine · 2025Article
- Perceived neighborhood safety, crime exposure, and chronic diseases among older Indians: The role of functional disabilities.PLOS global public health · 2025Article
- Risk of mental health conditions in bereavement: a population-based analysis of lung cancer spouses.Frontiers in public health · 2025Article
- Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study.GeroScience · 2024Article
- Depression and anxiety symptoms among Afghan war widows and their associated factors: A cross-sectional analytical study.Indian journal of psychiatry · 2024Article
- Nontraditional models as research tools: the road not taken.Trends in molecular medicine · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Losing a spouse is considered one of the most stressful life events a person can experience. Particularly in the immediate weeks and months after the loss, bereavement is associated with a significantly increased risk of morbidity and mortality. Despite an abundance of research aimed at identifying risk factors for adverse health outcomes following marital death, the mechanisms through which mental and physical health problems emerge following bereavement remain poorly understood. To address this issue, the present review examines several pathways that may link bereavement and health, including inflammation and immune dysregulation, genetic and epigenetic changes, gut microbiota activity, and biological aging. We then describe how these processes may be viewed from the perspective of the Social Signal Transduction Theory of Depression to provide a novel framework for understanding individual differences in long-term trajectories of adjustment to interpersonal loss. Finally, we discuss several avenues for future research on psychobiological mechanisms linking bereavement with mental and physical health outcomes.
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Registered trials
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