ReviewFrontiers in physiology2020
Considerations for the Analysis of Small Extracellular Vesicles in Physical Exercise.
Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Exercise-mediated extracellular vesicle-derived non-coding RNAs and cardiovascular protection: mechanistic insights and bibliometric analysis.Frontiers in physiology · 2026Pooled it
- Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review.Journal of cardiovascular translational research · 2023Pooled it
- Do Exercise-Induced Extracellular Vesicles Carry Cognitive Benefits to the Brain?Traffic (Copenhagen, Denmark) · 2026Article
- Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review).International journal of molecular medicine · 2026Review
- Neighborhood socioeconomic deprivation and physical activity associate with extracellular vesicle size and cargo in a community-based cohort of women.Scientific reports · 2026Article
- Exercise-derived extracellular vesicles in oncology: a new frontier for translational nanomedicine.Journal of translational medicine · 2026Review
- Exosome and miRNA Content Engagement in the Physical Exercise Response: What Is Known to Date in Atheltic Horses?International journal of molecular sciences · 2026Review
- Stress type-specific small extracellular vesicle signatures reflect divergent biological responses to acute psychosocial and physical challenges Do I understand correctly that there were no queries regarding the manuscript?Scientific reports · 2025Article
- The Role of miRNAs and Extracellular Vesicles in Adaptation After Resistance Exercise: A Review.Current issues in molecular biology · 2025Review
- The Impact of the Competition on miRNA, Proteins, and Metabolites in the Blood Exosomes of theGenes · 2025Article
- Advances in the mechanism of small extracellular vesicles promoting the development of hepatocellular carcinoma through multi-network fusion.Frontiers in immunology · 2025Review
- From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment.Journal of extracellular vesicles · 2024Review
- Editorial: Developmental biology and endocrine research for a successful pregnancy.Frontiers in endocrinology · 2024Article
- Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise.The Journal of physiology · 2023Article
- Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles.Comprehensive Physiology · 2023Article
- The Influence of Exercise-Associated Small Extracellular Vesicles on TrophoblastsBiomedicines · 2023Article
- Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight.Acta physiologica (Oxford, England) · 2022Article
- Acute changes in free and extracellular vesicle-associated circulating miRNAs and myokine profile in professional sky-runners during the Gran Sasso d'Italia vertical run.Frontiers in molecular biosciences · 2022Article
- Kinetics and Topology of DNA Associated with Circulating Extracellular Vesicles Released during Exercise.Genes · 2021Article
- Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor-Immune Interactions.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise induces acute physiological changes leading to enhanced tissue cross-talk and a liberation of extracellular vesicles (EVs) into the circulation. EVs are cell-derived membranous entities which carry bioactive material, such as proteins and RNA species, and are important mediators of cell-cell-communication. Different types of physical exercise interventions trigger the release of diverse EV subpopulations, which are hypothesized to be involved in physiological adaptation processes leading to health benefits and longevity. Large EVs ("microvesicles" and "microparticles") are studied frequently in the context of physical exercise using straight forward flow cytometry approaches. However, the analysis of small EVs (sEVs) including exosomes is hampered by the complex composition of blood, confounding the methodology of EV isolation and characterization. This mini review presents a concise overview of the current state of research on sEVs released upon physical exercise (ExerVs), highlighting the technical limits of ExerV analysis. The purity of EV preparations is highly influenced by the co-isolation of non-EV structures in the size range or density of EVs, such as lipoproteins and protein aggregates. Technical constraints associated with EV purification challenge the quantification of distinct ExerV populations, the identification of their cargo, and the investigation of their biological functions. Here, we offer recommendations for the isolation and characterization of ExerVs to minimize the effects of these drawbacks. Technological advances in the ExerV research field will improve understanding of the inter-cellular cross-talk induced by physical exercise leading to health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.