ArticleFrontiers in human neuroscience2020
Prefrontal Cortex and Amygdala Subregion Morphology Are Associated With Obesity and Dietary Self-control in Children and Adolescents.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder.Scientific reports · 2026Trial
- Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders.bioRxiv : the preprint server for biology · 2026Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- Altered asymmetry of amygdala volume mediates food addiction and weight gain.Journal of behavioral addictions · 2025Article
- Neural Correlates of Obesity and Inflammation in Children and Adolescents with Congenital Adrenal Hyperplasia.Hormone research in paediatrics · 2025Article
- Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates.Biological psychiatry · 2024Article
- Association of Overweight and Obesity with Impaired Executive Functioning in Mexican Adolescents: The Importance of Inhibitory Control.Healthcare (Basel, Switzerland) · 2024Article
- Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018.JAMA network open · 2023Article
- Obesity is associated with decreased gray matter volume in children: a longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Bidirectional Associations Between Adiposity and Cognitive Function and Mediation by Brain Morphology in the ABCD Study.JAMA network open · 2023Article
- Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective.Frontiers in neuroscience · 2023Review
- TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation.International journal of obesity (2005) · 2022Article
- Eating contexts determine the efficacy of nutrient warning labels to promote healthy food choices.Frontiers in nutrition · 2022Article
- Neonatal amygdala microstructure mediates the relationship between gestational glycemia and offspring adiposity.BMJ open diabetes research & care · 2021Article
- Developmental Changes in Food Perception and Preference.Frontiers in psychology · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
A prefrontal control system that is less mature than the limbic reward system in adolescence is thought to impede self-regulatory abilities, which could contribute to poor dietary choices and obesity. We, therefore, aimed to examine whether structural morphology of the prefrontal cortex (PFC; involved in cognitive control) and the amygdala (a key brain region for reward-related processing) are associated with dietary decisions and obesity in children and adolescents. Seventy-one individuals between the ages of 8-22 years (17.35 ± 4.76 years, 51% female, 56% were overweight or obese) participated in this study; each participant completed a computer-based food choice task and a T1- and T2-weighted structural brain scans. Two indices of obesity were assessed, including age- and sex-specific body mass index (BMIz) and waist-to-height ratio (WHtR). The behavioral task included rating 60 food stimuli for tastiness, healthiness, and liking. Based on each participant's self-ratings, 100 binary food choices were then made utilizing a computer mouse. Dietary "self-control" was calculated as the proportion of trials where the individual chose the healthier food item (vs. the tastier food item) over the total number of trials. Cortical thickness and amygdala subnuclei volumes were quantified using FreeSurfer 6.0 and CIT168 atlas, respectively. We found that WHtR was negatively associated with the thickness of bilateral superior frontal, left superior temporal, right insula, and right inferior temporal regions (
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