Evidence map›Paper›PMID 33343029›Full record

ArticleThe journal of extra-corporeal technology2020

Use of del Nido Cardioplegia for Adult Heart Surgery: How Long Is Not Too Long?

Goh Si Guim, Cindy Goh Wah Hoon, Clara Anne Lim, Huang Shoo Chay-Nancy, Ashlynn Ai Li Ler, Qi Xuan Lim, Nurdiyana Binte Jaafar, Cheryl Lim, Faizus Sazzad, Theo Kofidis

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PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of extra-corporeal technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
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  6. Academic Perfusion at Its Best and a New Tradition.The journal of extra-corporeal technology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Goh Si GuimPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Cindy Goh Wah HoonPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Clara Anne LimPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Huang Shoo Chay-NancyPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Ashlynn Ai Li LerPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Qi Xuan LimPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Nurdiyana Binte JaafarPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Cheryl LimPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Faizus SazzadPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Theo KofidisPerfusion Services, Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore, Singapore; School of Medicine, National University of Ireland, Galway, Ireland; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most apparent practical advantage of del Nido cardioplegia (DNC) is that it allows the surgeon a longer arrest period before a subsequent dose is needed, as opposed to the conventional St. Thomas' cardioplegia solution where the recommended ischemic time is ∼15-20 minutes. In this study, we explored the incidence of arrhythmia after cross-clamp removal as a surrogate for a safe myocardial ischemic time with the use of DNC in adult heart surgery. A total of 113 patients who had undergone heart valve repair and/or replacement surgery at the National University Hospital, Singapore, were investigated. This single-center retrospective study was conducted on a population where DNC had been used for myocardial protection between January 2017 and April 2019. Cardioplegia ischemic time interval groups were not significant predictors of postoperative arrhythmia, defibrillation, and intraoperative intra-aortic balloon pump usage. Crude comparison of postoperative outcomes showed no significant differences in any other postoperative variables, including mortality and total hospital stay. From the results of the present study, it appears that there is no optimal ischemic time interval for the administration of DNC within a 120-minute time period. It is likely that DNC has a redosing interval of, and may provide adequate myocardial protection, for up to 120 minutes.

Indexed as

Cardiac Surgical ProceduresHeart Arrest, InducedAdultCardioplegic SolutionsHumansPostoperative PeriodRetrospective StudiesCardioplegic Solutionsarrhythmiacardioplegiadefibrillationdel Nidodosingischemia/reperfusionstatistics/regression analysistiming

Identifiers

PMID33343029
PMCPMC7728503
OpenAlexW3114680138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.