Evidence map›Paper›PMID 33343021›Full record

ArticleIEEE journal of solid-state circuits2020

Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring.

Jun-Chau Chien, Sam W Baker, H Tom Soh, Amin Arbabian

Open access · greenAbstract read
In one paragraph

Article in IEEE journal of solid-state circuits, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Wireless Implantable Closed-Loop Electrochemical Drug Delivery System.IEEE transactions on biomedical circuits and systems · 2025
    Article
  7. Generalizable Molecular Switch Designs forAccounts of chemical research · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Long-TermbioRxiv : the preprint server for biology · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jun-Chau ChienDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305 USA.
Sam W BakerDepartment of Comparative Medicine, Stanford University, Stanford, CA 94305 USA.
H Tom SohDepartment of Radiology and the Department of Electrical Engineering, Stanford University, Stanford, CA 94305 USA.
Amin ArbabianDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305 USA.
Stanford University · US

Funding

Real-time biosensor for mapping the function of the pancreasOT2OD025342 · OD · STANFORD UNIVERSITY · PI SOH, HYONGSOK TOM · 2018 to 2021
$4.6M
A Wireless, Implantable Microdevice for Closed-Loop Drug Delivery to Prevent the Morbidity of Diabetes Therapy-Induced HypoglycemiaR01EB025867 · NIBIB · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2018 to 2021
$2.2M
In vivo Wireless Sensors for Gut Redox Monitoring to Understand Host and Microbe PhysiologyR21AI163489 · NIAID · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2021 to 2022
$434k
NIAID NIH HHS R21 AI163489NIBIB NIH HHS R01 EB025867NIH HHS OT2 OD025342
6 · The paper itself

Abstract

In this paper, we present the design and the analysis of an electrochemical circuit for measuring the concentrations of therapeutic drugs using structure-switching aptamers. Aptamers are single-stranded nucleic acids, whose sequence is selected to exhibit high affinity and specificity toward a molecular target, and change its conformation upon binding. This property, when coupled with a redox reporter and electrochemical detection, enables reagent-free biosensing with a sub-minute temporal resolution for

Indexed as

aminoglycosideAptamerchronoamperometryCMOSDNAelectrochemical detectionelectron transfer kineticsimplantablein vivo monitoringkanamycinmethylene bluepersonalized drug dosingpharmacokineticsprecision medicineprincipal component analysissample-and-hold circuitsquare-wave voltammetrywearable

Identifiers

PMID33343021
PMCPMC7742970
OpenAlexW3021078164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.