Evidence map›Paper›PMID 33342766›Full record

ArticleAging2020

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways.

Songtao An, Xi Wang, Huairui Shi, Xueqiang Zhang, Hua Meng, Wenbo Li, Dongchang Chen, Junbo Ge

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

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  18. The Yin and Yang Effect of the Apelinergic System in Oxidative Stress.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Songtao AnDepartment of Cardiology, Henan Province People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Xi WangDepartment of Cardiology, Henan Province People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Huairui ShiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Xueqiang ZhangDepartment of Cardiology, Hongxing Hospital, Hami 839000, Xinjiang, China.
Hua MengDepartment of Cardiology, Henan Province People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Wenbo LiDepartment of Cardiology, Henan Province People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Dongchang ChenDepartment of Cardiology, Henan Province People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhengzhou People's Hospital · CNZhengzhou University · CNFudan University · CNSun Yat-sen University · CNTang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among all diabetes mellitus-associated cardiovascular diseases, morbidity of diabetic myocardium with ischemia reperfusion injury (D-IRI) is increasing year by year. We aimed to discover a therapeutic biomarker and investigate its mechanism in D-IRI. High-fat diet and streptozotocin-induced diabetes rats were operated with IRI or sham. Recombined lentiviral vector encoding Apelin was injected into D-IRI rat via tail vein. Cardiac function, infarct size, cellular death and oxidative stress were major outcome measures. Cardiomyocyte ischemia reperfusion injury was more serious in D-IRI rats than in non-diabetes ischemia reperfusion injury (ND-IRI) rats. The secretion of NTproBNP was increased in D-IRI compared with ND-IRI. Bcl-2 expression was decreased, and Bax and cleaved caspase-3 expression was increased in D-IRI rats compared with ND-IRI rats, which were reversed after treatment with Apelin. Apelin-upregulation improved cardiomyocyte ischemia reperfusion injury and decreased NT-proBNP levels in D-IRI rats. Apelin overexpression enhanced PI3K and eNOS levels while reduced those of p38-MAPK and iNOS in D-IRI rats. Apelin overexpression protected against D-IRI through inhibiting apoptosis and oxidative stress via PI3K and p38MAPK signaling pathways in D-IRI rats. These findings provide critical new insight into understanding of Apelin's cardio-protective effects, which may become a novel therapeutic target for the diabetic IRI patients.

Indexed as

AnimalsApelinApoptosisbcl-2-Associated X ProteinCaspase 3Cell DeathDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Genetic TherapyMAP Kinase Signaling SystemMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacNatriuretic Peptide, BrainNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIApelinBax protein, ratbcl-2-Associated X ProteinBcl2 protein, ratCasp3 protein, ratCaspase 3Natriuretic Peptide, BrainNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINos2 protein, ratNos3 protein, ratPeptide FragmentsPhosphatidylinositol 3-Kinasespro-brain natriuretic peptide (1-76)Proto-Oncogene Proteins c-bcl-2apelindiabetic myocardial ischemia reperfusion injuryischemia and type 2 diabetic mellitusoxidative stress

Identifiers

PMID33342766
PMCPMC7803490
OpenAlexW3117931285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.