ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2021
Prognostic impact and clinical outcomes of coronary flow reserve and hyperaemic microvascular resistance.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial.Nature medicine · 2026Trial
- Review
- Coronary Flow Reserve in Adults: Pathophysiology, Assessment Modalities, Clinical Applications, and Prognostic Significance.Medicina (Kaunas, Lithuania) · 2026Review
- Prevalence and Predictors of Impaired Coronary Flow Velocity Reserve in Adolescents After Arterial Switch Operation.Diagnostics (Basel, Switzerland) · 2026Article
- Exploring coronary microvascular dysfunction from functional impairment and structural damage.Frontiers in cardiovascular medicine · 2025Review
- Coronary Microvascular Dysfunction: Insights on Prognosis and Future Perspectives.Reviews in cardiovascular medicine · 2025Review
- Novel diagnostic approaches and management of coronary microvascular dysfunction.American journal of preventive cardiology · 2024Article
- Diagnostic Yield of Comprehensive Coronary Function Testing in Patients with Angina and Unobstructed Coronary Arteries: Endotype Characterisation and Clinical Implications.European cardiology · 2024Article
- Coronary microvascular dysfunction is an independent predictor of developing cancer in patients with non-obstructive coronary artery disease.European journal of preventive cardiology · 2023Article
- Invasive Detection of Coronary Microvascular Dysfunction: How It Began, and Where We Are Now.Interventional cardiology (London, England) · 2023Review
- Coronary microvascular dysfunction in heart failure patients.Frontiers in cardiovascular medicine · 2023Review
- Article
- Coronary Microvascular Angina: A State-of-the-Art Review.Frontiers in cardiovascular medicine · 2022Review
- Machine learning aids clinical decision-making in patients presenting with angina and non-obstructive coronary artery disease.European heart journal. Digital health · 2021Article
- Stratifying cardiovascular risk in patients with microvascular dysfunction: new insights from emerging physiology metrics.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Risk Stratification of Patients With NonObstructive Coronary Artery Disease Using Resistive Reserve Ratio.Journal of the American Heart Association · 2021Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundMost studies dichotomise indices of coronary microvascular function to assess their prognostic values.
aimsWe aimed to investigate whether coronary flow reserve (CFR) and hyperaemic microvascular resistance (HMR) as continua predict major adverse cardiovascular events (MACE), comprising all-cause death, myocardial infarction, revascularisation, and stroke in patients with ischaemia and non-obstructive coronary artery disease.
methodsA total of 610 patients were included and followed up over a median of 8.0 years (199 individual MACE in 174 patients).
resultsBoth CFR and HMR as continua predicted MACE with an odds ratio (OR) of 0.70 (per 1-unit increase, 95% confidence interval [CI]: 0.53, 0.92; p=0.01) and 1.63 (per 1 mmHg/cm/s, 95% CI: 1.20, 2.21; p=0.002), respectively. This relationship remained significant after adjustment for age and sex with an adjusted OR of 0.66 (per 1 unit increase, 95% CI: 0.49, 0.89; p=0.01) and 1.42 (per 1 mmHg/cm/s, 95% CI: 1.03, 1.94; p=0.03). HMR added prognostic value to CFR in predicting MACE (net reclassification index 0.17, 95% CI: 0.02, 0.31; p=0.03; integrated discrimination improvement 0.01, 95% CI: 0.0001, 0.02; p=0.046).
conclusionsBoth CFR and HMR as continuous variables predict future risk of MACE.
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Registered trials
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