ReviewBiological psychiatry2021
An Adolescent Sensitive Period for Threat Responding: Impacts of Stress and Sex.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health.Molecular psychiatry · 2026Review
- [Youth mental health: early detection and early intervention of mental disorders].Der Nervenarzt · 2026Review
- Sex differences in response to violence: role of salience network expansion and connectivity on depression.Translational psychiatry · 2025Article
- Safety learning during adolescence facilitates fear regulation in adult mice.Developmental cognitive neuroscience · 2025Article
- Long-lasting Depressive Behavior of Adolescent Chronically Stressed Mice is Mediated by Gut Microbiota Dysbiosis.Molecular neurobiology · 2025Article
- Youth mental health crisis: A translational view of the COVID-19 pandemic.Neurobiology of stress · 2025Review
- Developmentally distinct architectures in top-down pathways controlling threat avoidance.Nature neuroscience · 2025Article
- Associations between trajectories of depressive symptoms and cognitive performance in Chinese adolescents.BMC psychology · 2025Article
- Environmental Enrichment Has Age- and Sex-Specific Effects on Fear Regulation in Mice.Developmental psychobiology · 2025Article
- The Role of Puberty and Sex on Brain Structure in Adolescents With Anxiety Following Concussion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Facing ambiguity: Social threat sensitivity mediates the association between peer victimization and adolescent anxiety.Development and psychopathology · 2024Article
- Violence victimisation and young adult cardiometabolic health: the role of timing and social identity.Annals of human biology · 2024Article
- From air to mind: unraveling the impact of indoor pollutants on psychiatric disorders.Frontiers in psychiatry · 2024Review
- Intermixed safety cues facilitate extinction retention in adult and adolescent mice.Physiology & behavior · 2023Article
- Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice.Developmental psychobiology · 2023Article
- Through a Developmental Lens: Emerging Insights to Understand and Treat Pediatric PTSD.The American journal of psychiatry · 2023Review
- Towards a youth mental health paradigm: a perspective and roadmap.Molecular psychiatry · 2023Review
- Investigating Links between Moderate-to-Vigorous Physical Activity and Self-Rated Health Status in Adolescents: The Mediating Roles of Emotional Intelligence and Psychosocial Stress.Children (Basel, Switzerland) · 2023Article
- Maturation of a cortical-amygdala circuit limits sociability in male rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety.Biological psychiatry global open science · 2023Review
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Authors and funding
3 authors.
Funding
Abstract
Anxiety and fear-related disorders peak in prevalence during adolescence, a window of rapid behavioral development and neural remodeling. However, understanding of the development of threat responding and the underlying neural circuits remains limited. Preclinical models of threat conditioning and extinction have provided an unparalleled glimpse into the developing brain. In this review we discuss mouse and rat studies on the development of threat response regulation, with a focus on the adolescent period. Evidence of nonlinear patterns of threat responding during adolescence and the continued development of the underlying circuitry is highly indicative of an adolescent sensitive period for threat response regulation. While we highlight literature in support of this unique developmental window, we also emphasize the need for causal studies to clarify the parameters defining such a sensitive period. In doing so, we explore how stress and biological sex affect the development and expression of threat response regulation during adolescence and beyond. Ultimately, a deeper understanding of how these factors interact with and affect developmental trajectories of learning and memory will inform treatment and prevention strategies for pediatric anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.