ArticleHypertension (Dallas, Tex. : 1979)2021
Association of Cumulative Systolic Blood Pressure With Long-Term Risk of Cardiovascular Disease and Healthy Longevity: Findings From the Lifetime Risk Pooling Project Cohorts.
Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 76 citations in OpenAlex.
- Educational Attainment and the Effect of Intensive Blood Pressure Reduction: A Post Hoc Analysis of the SPRINT Study.Journal of the American Heart Association · 2025Trial
- Effects of salt substitution on cumulative blood pressure: a secondary analysis of the SSaSS.European journal of epidemiology · 2025Trial
- Blood pressure targets in adults with hypertension.The Cochrane database of systematic reviews · 2026Article
- A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.Nature medicine · 2026Article
- Life-Course Blood Pressure Levels, 38-Year Tracking, and Prediction of Hypertension.Journal of the American Heart Association · 2026Article
- Five-year cardiovascular outcomes across hypertensive disorders of pregnancy subtypes: a propensity-matched analysis.Frontiers in cardiovascular medicine · 2026Article
- Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease.European heart journal · 2025Article
- Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.European journal of preventive cardiology · 2025Observational
- Cumulative remnant cholesterol and major adverse cardiovascular events among adults with type 2 diabetes.American journal of preventive cardiology · 2025Article
- Association of Cardiovascular Health and Time Lived With Zero Coronary Artery Calcium.JACC. Cardiovascular imaging · 2025Observational
- Comparison of the cumulative exposure to four measures of blood pressure for predicting cardiovascular disease risk in the Chinese Uyghurs.BMC public health · 2025Article
- Hypertension Phenotypes and Mortality Risk in the United States of America: A Data-Driven Cluster Analysis.International journal of hypertension · 2025Article
- Linking extent of return to fasting state after oral glucose tolerance test to future risk of prediabetes and type 2 diabetes: Insights from the TLGS.Journal of diabetes investigation · 2024Article
- Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years.European journal of preventive cardiology · 2024Article
- Prediction of Cumulative Exposure to Atherogenic Lipids During Early Adulthood.Journal of the American College of Cardiology · 2024Article
- Life's Essential 8 Cardiovascular Health Score and Cardiorespiratory Fitness in the Community.Journal of the American Heart Association · 2024Article
- Blood pressure and the hypertension care cascade in The Gambia: Findings from a nationwide survey.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Incorporating longitudinal history of risk factors into atherosclerotic cardiovascular disease risk prediction using deep learning.Scientific reports · 2024Article
- Article
- Effect of 10-year cumulative blood pressure exposure on atherosclerotic cardiovascular disease of different age groups: kailuan cohort study.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Hypertension is a major risk factor for cardiovascular disease (CVD), but previous studies have mostly been limited to a single exam, a single cohort, a short follow-up period, or a limited number of outcomes. This study aimed to assess the association of 10-year cumulative systolic blood pressure (BP) in middle age with long-term risk of any CVD, coronary heart disease, stroke, heart failure, all-cause mortality, and healthy longevity. Individuals (11 502) from 5 racially/ethnically diverse US community-based cohorts were included in this study once they met all the inclusion criteria: ≥10 year of observation in the included cohort, aged 45 to 60 years, free of CVD, and had ≥3 visits with BP exams over the preceding 10 years. For each participant, systolic BP level was predicted for each year of the 10-year prior inclusion, based on the available exams (median of 4.0; spread over, 9.1 [range, 7.2-10] years). Lower 10-year cumulative systolic BP was associated with 4.1 years longer survival and 5.4 years later onset of CVD, resulting in living longer life with a shorter period with morbidity. Models adjusted for sociodemographic characteristics, cardiovascular risk factors, and index systolic BP demonstrated associations of 10-year cumulative systolic BP (per 130 mm Hg×year change, the threshold for stage-1 hypertension) with CVD (hazard ratio [HR], 1.28 [95% CI, 1.20-1.36]), coronary heart disease (HR, 1.29 [95% CI, 1.19-1.40]), stroke (HR, 1.33 [95% CI, 1.20-1.47]), heart failure (HR, 1.12 [95% CI, 1.02-1.23]), and all-cause mortality (HR, 1.21 [95% CI, 1.14-1.29]). These findings emphasize the importance of 10-year cumulative systolic BP as a risk factor to CVD, above and beyond current systolic BP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.