ArticleArthritis care & research2022
Lifetime Allergy Symptoms in IgG4-Related Disease: A Case-Control Study.
Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Correlations between IgG4-related disease, autoimmune pancreatitis, and allergic diseases.Frontiers in immunology · 2026Review
- Current and future advances in practice: IgG4-related disease.Rheumatology advances in practice · 2024Review
- IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease.Frontiers in immunology · 2024Review
- Assessment of patient-reported symptoms and distress in IgG4-related disease (IgG4-RD): Development, clinical validation, and content validation of the IgG4-RD Symptom Severity Index.Seminars in arthritis and rheumatism · 2023Article
- Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Implication of allergy and atopy in IgG4-related disease.The World Allergy Organization journal · 2023Review
- The Positive Predictive Value of a Very High Serum IgG4 Concentration for the Diagnosis of IgG4-Related Disease.The Journal of rheumatology · 2023Article
- Article
- IgG4-related diseases involving pleura: a case report and literature review.Frontiers in medicine · 2023Article
- Derivation and Validation of Algorithms to Identify Patients With Immunoglobulin-G4-Related Disease Using Administrative Claims Data.ACR open rheumatology · 2022Article
- Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease.Scientific reports · 2021Article
- IgG4-Related Disease With Tuberculosis: A Case Report and Retrospective Review of Patients in a Single Center.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe etiology of IgG4-related disease (IgG4-RD) is unknown, and there has been controversy over the significance of allergic conditions in IgG4-RD. We examined the prevalence of lifetime allergy symptoms in IgG4-RD and the association between these and IgG4-RD.
methodsWe identified IgG4-RD patients and non-IgG4-RD controls without autoimmune conditions seen at a single center. IgG4-RD patients were classified using the American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria. Allergy symptoms were ascertained by questionnaire. We assessed the association of IgG4-RD features with allergy symptoms. We compared the proportion of cases and controls with allergy symptoms using conditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) after matching cases and controls 1:1 by age and sex.
resultsLifetime allergy symptoms were reported by 165 (71%) of 231 IgG4-RD patients. Aeroallergen symptoms were most commonly reported (n = 135, 58%), followed by skin allergy symptoms (n = 97, 42%) and food allergy symptoms (n = 47, 20%). IgG4-RD cases with a history of allergy symptoms were more likely to have head and neck involvement (OR 2.0 [95% CI 1.1-3.6]) and peripheral eosinophilia (OR 3.3 [95% CI 1.2-9.0]) than those without allergy symptoms. The prevalence of any allergy symptoms was similar between cases and controls (OR 0.7 [95% CI 0.4-1.1]); this remained consistent after stratifying by head and neck involvement.
conclusionLifetime allergy symptoms are common in IgG4-RD but are not reported more often in IgG4-RD compared to non-IgG4-RD patients without autoimmune conditions. These findings suggest that allergies are not uniquely associated with the pathogenesis or presentation of IgG4-RD.
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