Evidence map›Paper›PMID 33341979›Full record

ArticleEquine veterinary journal2021

Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses.

Taisuke Kuroda, Yohei Minamijima, Hidekazu Niwa, Norihisa Tamura, Hiroshi Mita, Kentaro Fukuda, Masahiro Kaimachi, Yuto Suzuki, Yuki Enoki, Kazuaki Taguchi and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Equine veterinary journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Taisuke KurodaClinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.ORCID https://orcid.org/0000-0002-3709-5459
Yohei MinamijimaDrug Analysis Department, Laboratory of Racing Chemistry, Utsunomiya, Japan.ORCID https://orcid.org/0000-0002-2096-0784
Hidekazu NiwaMicrobiology Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Norihisa TamuraClinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.ORCID https://orcid.org/0000-0002-9138-6839
Hiroshi MitaClinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Kentaro FukudaClinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Masahiro KaimachiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy Tokyo, Japan.
Yuto SuzukiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy Tokyo, Japan.
Yuki EnokiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy Tokyo, Japan.
Kazuaki TaguchiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy Tokyo, Japan.
Kazuaki MatsumotoDivision of Pharmacodynamics, Keio University Faculty of Pharmacy Tokyo, Japan.
Pierre-Louis ToutainComparative Biomedical Sciences, The Royal Veterinary College, London, UK.ORCID https://orcid.org/0000-0002-8846-8892
Alain Bousquet-MelouINTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France.
Yoshinori KasashimaClinical Veterinary Medicine Division Equine Research Institute, Japan Racing Association, Shimotsuke, Japan.
Japan Racing Association · JPKeio University · JPÉcole Nationale Vétérinaire de Toulouse · FRLaboratory of Racing Chemistry · JPRoyal Veterinary College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFirst-generation cephalosporins have good activity against gram-positive bacteria and are extensively used in horses. There are few reports of pharmacokinetics and pharmacodynamics (PK/PD) analysis of cephalosporins in horses.

objectiveTo optimise the dosages of the two first-generation cephalosporins cephalothin (CET) and cefazolin (CEZ) in horses using PK/PD concepts. STUDY

designExperimental study with single administration.

methodsDrug plasma concentrations following a single intravenous (i.v.) administration of 22 mg/kg bodyweight (bwt) CET in 12 horses and of 10 mg/kg bwt CEZ in six horses were measured using LC-MS/MS. Data were modelled using a nonlinear mixed effect modelling followed by Monte Carlo simulations. Minimum inhibitory concentrations (MICs) against Streptococcus zooepidemicus and Staphylococcus aureus isolated from horses were determined by the microbroth dilution method.

resultsThe percentages of CET and CEZ binding to serum proteins were 19.9% ± 8.4% and 15.2% ± 8.5% respectively. For both CET and CEZ, the MIC MAIN LIMITATIONS: Small sample size only in healthy horses.

conclusionsFor CET, more frequent administration than that currently recommended (22 mg/kg bwt q6-12h) is required to empirically control S. aureus infection in horses. For CEZ, less frequent administration compared to the dosage regimen currently proposed (10-22 mg/kg bwt q6h) could control S. zooepidemicus and S. aureus infections in horses.

Indexed as

CefazolinCephalothinAnimalsAnti-Bacterial AgentsChromatography, LiquidHorsesMicrobial Sensitivity TestsStaphylococcus aureusTandem Mass SpectrometryAnti-Bacterial AgentsCefazolinCephalothincefazolincephalothingram positive infectionhorse

Identifiers

PMID33341979
PMCPMC8518962
OpenAlexW3115076607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.