Evidence map›Paper›PMID 33341918›Full record

ArticleAnnals of hematology2021

Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.

Linus Angenendt, Isabel Hilgefort, Jan-Henrik Mikesch, Bernhard Schlüter, Wolfgang E Berdel, Georg Lenz, Matthias Stelljes, Christoph Schliemann

Open access · hybridAbstract read
In one paragraph

Article in Annals of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Linus AngenendtDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. angenendt@uni-muenster.de.ORCID http://orcid.org/0000-0003-2502-9910
Isabel HilgefortDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Jan-Henrik MikeschDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Bernhard SchlüterCentre for Laboratory Medicine, University Hospital Münster, Münster, Germany.
Wolfgang E BerdelDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Georg LenzDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Matthias StelljesDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Christoph SchliemannDepartment of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
University Hospital Münster · DE

Funding

Deutsche Forschungsgemeinschaft DFG EXC 1003Horizon 2020 Eurostars-2 Project E!11969 ('ComPAIR')Innovative Medical Research Fund of the University of Münster Medical School AN111813
6 · The paper itself

Abstract

Low intake of magnesium has been associated with the occurrence of lymphomas and decreased magnesium levels suppress the cytotoxic function of T cells and natural killer cells in patients with "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia" (XMEN) syndrome. These cell types are also important mediators of immune-mediated effects after allogeneic hematopoietic stem cell transplantation. Here, we show that high posttransplant magnesium levels independently associate with a lower incidence of relapse, a higher risk of acute graft-versus-host disease, and a higher non-relapse mortality in 368 patients with acute myeloid leukemia from our center. Magnesium serum levels might impact on donor-cell-mediated immune responses in acute myeloid leukemia.

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentAdultAgedFemaleFollow-Up StudiesGraft vs Host DiseaseGraft vs Leukemia EffectHumansLeukemia, Myeloid, AcuteMagnesiumMaleMiddle AgedPrognosisRetrospective StudiesTransplantation, HomologousMagnesiumAcute myeloid leukemiaAllogeneic hematopoietic stem cell transplantationGVHDGVLMagnesium

Identifiers

PMID33341918
PMCPMC8195955
OpenAlexW3114197616

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.