Evidence map›Paper›PMID 33341585›Full record

ArticleEnvironment international2021

Young children's exposure to phenols in the home: Associations between house dust, hand wipes, silicone wristbands, and urinary biomarkers.

Jessica L Levasseur, Stephanie C Hammel, Kate Hoffman, Allison L Phillips, Sharon Zhang, Xiaoyun Ye, Antonia M Calafat, Thomas F Webster, Heather M Stapleton

Abstract read
In one paragraph

Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Article
  3. A transdisciplinary process-oriented approach to evaluate infant exposure to indoor dust.Journal of exposure science & environmental epidemiology · 2026
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  10. Young infants' exposure to parabens: lotion use as a potential source of exposure.Journal of exposure science & environmental epidemiology · 2025
    Article
  11. Article
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  14. An Assessment of Multipollutant Exposures Using Silicone Wristbands Among Bangladeshi Youth.International journal of environmental research and public health · 2024
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica L LevasseurNicholas School of Environment, Duke University, Durham, NC, United States. Electronic address: jessica.levasseur@duke.edu.
Stephanie C HammelNicholas School of Environment, Duke University, Durham, NC, United States; Children's Health Discovery Initiative, Duke School of Medicine, NC, United States. Electronic address: stephanie.hammel@duke.edu.
Kate HoffmanNicholas School of Environment, Duke University, Durham, NC, United States; Children's Health Discovery Initiative, Duke School of Medicine, NC, United States. Electronic address: kate.hoffman@duke.edu.
Allison L PhillipsNicholas School of Environment, Duke University, Durham, NC, United States. Electronic address: phillips.allison@epa.gov.
Sharon ZhangNicholas School of Environment, Duke University, Durham, NC, United States. Electronic address: sz126@duke.edu.
Xiaoyun YeCenters for Disease Control and Prevention, Atlanta, GA, United States.
Antonia M CalafatCenters for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: aic7@cdc.gov.
Thomas F WebsterBoston University School of Public Health, Boston University, Boston, MA, United States. Electronic address: twebster@bu.edu.
Heather M StapletonNicholas School of Environment, Duke University, Durham, NC, United States; Children's Health Discovery Initiative, Duke School of Medicine, NC, United States. Electronic address: heather.stapleton@duke.edu.

Funding

Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Novel Analytical and Experimental Approaches for Predicting the Biological Effects of MixturesR01ES027813 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2017 to 2021
$2.2M
Development and Testing of Response Surface Methods for Investigating the Epidemiology of Exposure to MixturesR01ES028800 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2018 to 2021
$1.7M
NIEHS NIH HHS R01 ES016099NIEHS NIH HHS R01 ES027813NIEHS NIH HHS R01 ES028800NIEHS NIH HHS T32 ES021432
6 · The paper itself

Abstract

backgroundEnvironmental phenols, such as parabens, bisphenol A, and triclosan, are ubiquitous in indoor environments because of their use in packaging, plastics, personal care products, and as anti-microbials. The primary pathways of exposure, as well as habits and behaviors that may lead to greater exposure, are still unclear.

objectivesHerein, we investigate the relationships between phenols found in residential environments by comparing levels in paired samples of house dust and hand wipes with children's urine. In addition, phenols were analyzed in a novel exposure tool, the silicone wristbands, to investigate which external matrix best correlates with individual exposure based on urinary phenol biomarkers.

methodsChildren aged 3-6 years in central North Carolina, United States, provided paired hand wipe (n = 202), wristband (n = 76), and spot urine samples (n = 180), while legal guardians completed questionnaires on habits and behaviors. House dust samples (n = 186) were collected from the main living area during home visits completed between 2014 and 2016.

resultsEnvironmental phenols were detected frequently in all matrices investigated. Ethyl, methyl, and propylparaben levels observed in hand wipes, dust, and on wristbands were significantly correlated to their associated urinary biomarkers. In addition, intra-paraben correlations were noted, with biomarkers of ethyl, methyl, and propylparabens generally positively and significantly correlated, which suggests co-application of parabens in products. Triclosan levels in dust were positive and significantly correlated with levels in hand wipes and wristbands and with urinary concentrations, suggesting non-personal care product sources may be important in children's overall triclosan exposure. Generally, chemicals on wristbands were more highly correlated with urinary biomarkers than with chemicals in hand wipes or house dust. In addition, more frequent lotion use was positively associated with urinary concentrations of paraben biomarkers.

conclusionsOur results suggest that the home environment is an important source of exposure which has been under-investigated for some environmental phenols (e.g., triclosan in house dust). Associations between wristbands and biomarkers of exposure, which were stronger than for hand wipes and house dust, suggest that silicone wristbands may provide a suitable exposure assessment tool for some phenols.

Indexed as

DustSiliconesBiomarkersChildChild, PreschoolEnvironmental ExposureEnvironmental MonitoringHumansNorth CarolinaParabensPhenolsBiomarkersDustParabensPhenolsSiliconesBiomonitoringChildrenExposure assessmentHuman exposureParabensPhenolsSilicone wristbandTriclosanUrine

Identifiers

PMID33341585
PMCPMC7856225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.