ArticleRespiratory medicine2021
Multiple breath washout: A noninvasive tool for identifying lung disease in symptomatic military deployers.
Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03241420 (Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Welding Fumes and SARS-CoV-2: A Dangerous Combination.Journal of occupational and environmental medicine · 2026Article
- Respiratory symptoms and pulmonary physiologic outcomes among post-9/11 veterans with blast exposure.Frontiers in public health · 2026Article
- Deployment Exposures, Respiratory Symptoms, and the Limits of Resting Lung Function.Annals of the American Thoracic Society · 2025Article
- Reply to Holley and Morris: Postdeployment Respiratory Health: It's Not Always the Lungs.Annals of the American Thoracic Society · 2025Article
- Current understanding of the impact of United States military airborne hazards and burn pit exposures on respiratory health.Particle and fibre toxicology · 2024Review
- Longitudinal changes in lung function following post-9/11 military deployment in symptomatic veterans.Respiratory medicine · 2024Article
- Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry.BMJ open respiratory research · 2024Observational
- Deployment-Related Respiratory Disease: Where Are We?Seminars in respiratory and critical care medicine · 2023Review
- Postdeployment Respiratory Health: The Roles of the Airborne Hazards and Open Burn Pit Registry and the Post-Deployment Cardiopulmonary Evaluation Network.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022Article
- Relationship between clinician documented blast exposure and pulmonary function: a retrospective chart review from a national specialty clinic.Respiratory research · 2022Article
- Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers.BMC pulmonary medicine · 2022Article
- Multiple breath washout: measuring early manifestations of lung pathology.Breathe (Sheffield, England) · 2021Article
- Multiple breath washout test data for healthy controls.Data in brief · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleMilitary deployments to austere environments since November 9, 2001 may put "deployers" at risk for respiratory disease. Sensitive, noninvasive tools for detecting large and small airways injury are needed to identify early disease and help inform management for this at-risk population.
objectivesWe examined multiple breath washout (MBW) as a tool for identifying deployment-related airways disease and assessed host and exposure risk factors compared to healthy controls.
methodsBetween March 2015 and March 2020, 103 healthy controls and 71 symptomatic deployers with asthma and/or distal lung disease completed a questionnaire, spirometry and MBW testing. SAS v. 9.4 was used to compare MBW parameters between deployers and controls via univariate analyses and adjusted for demographic factors using multiple linear regression. MEASUREMENTS AND MAIN
resultsDeployers were significantly more likely than controls to have an abnormal lung clearance index (LCI) score indicating global ventilation inhomogeneity. Adjusting for sex, smoking status, smoking pack-years and body mass index, LCI scores were significantly more abnormal among those with deployment-related asthma and distal lung disease compared to controls. The unadjusted variable Sacin (a marker of ventilation inhomogeneity in the acinar airways) was higher and thus more abnormal in those with both proximal and distal airways disease. Deployers who reported more frequent exposure to explosive blasts had significantly higher LCI scores.
conclusionsThis study demonstrates the utility of MBW in evaluating exposure-related airways disease in symptomatic military personnel following deployment to austere environments, and is the first to link exposure to explosive blasts to measurable small airways injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.