ArticleDevelopmental cognitive neuroscience2021
Greater age-related changes in white matter morphometry following early life stress: Associations with internalizing problems in adolescence.
Article in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Effects of adverse childhood experiences on behavior in adolescence: Insights from brain imaging and genetic risk.Developmental cognitive neuroscience · 2026Article
- Longitudinal development of the anterior insula-nucleus accumbens white matter pathway through adolescence predicts risk taking in young adulthood.Developmental cognitive neuroscience · 2026Article
- Childhood white matter organization predicts adolescent internalizing problems among youth with and without ADHD.NeuroImage. Clinical · 2026Article
- Exposure to Fine Particulate Matter During Pregnancy Is Associated With Hippocampal Development in Offspring.Biological psychiatry global open science · 2025Article
- Approaching Temporal Dynamics in the Dimension-Level Associations Between Career Adaptability/Ambivalence and Internalizing Symptoms Among Chinese Adolescents Throughout Their High Middle School Years.Journal of youth and adolescence · 2024Article
- Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Implications of Inflammatory Processes on a Developing Central Nervous System in Childhood-Onset Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2024Review
- Associations of maternal emotion regulation with child white matter connectivity in Black American mother-child dyads.Developmental psychobiology · 2022Article
- Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.Translational psychiatry · 2022Article
- Signatures of life course socioeconomic conditions in brain anatomy.Human brain mapping · 2022Article
- An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms.Development and psychopathology · 2022Article
- Introduction to the special issue on childhood adversity and neurodevelopment.Developmental cognitive neuroscience · 2022Article
- Maternal Error-Related Negativity Relationship With Offspring Error-Related Negativity and Negative Parenting Styles: A Novel Model of Internalizing Psychopathology Risk.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Early life stress is associated with the default mode and fronto-limbic network connectivity among young adults.Frontiers in behavioral neuroscience · 2022Article
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Early life stress (ELS) is associated with increased risk for internalizing disorders and variations in gray matter development. It is unclear, however, whether ELS affects normative age-related changes in white matter (WM) morphology, and if such maturational differences are associated with risk for internalizing psychopathology. We conducted comprehensive interviews in a cross-sectional sample of young adolescents (N = 156; 89 F; Ages 9-14) to assess lifetime exposure to stress and objective cumulative ELS severity. We used diffusion-weighted imaging to measure WM fixel-based morphometry and tested the effects of age and ELS on WM fiber density and cross-section (FDC), and associations between WM FDC and internalizing problems. Age was positively associated with FDC in all WM tracts; greater ELS severity was related to stronger age-WM associations in several association tracts connecting the frontal lobes with limbic, parietal, and occipital regions, including bilateral superior and inferior longitudinal and uncinate fasciculi (UF). Among older adolescents with greater ELS severity, a higher UF FDC was associated with fewer internalizing problems. Greater ELS severity predicted more mature WM morphometry in tracts implicated in emotion regulation and cognitive processing. More phenotypically mature UF WM may be adaptive against internalizing psychopathology in adolescents exposed to ELS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.