Evidence map›Paper›PMID 33340768›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2021

Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues.

Zhichao Zhang, Shiva Emami, Marie Hennebelle, Rhianna K Morgan, Larry A Lerno, Carolyn M Slupsky, Pamela J Lein, Ameer Y Taha

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Foods (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhichao ZhangDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Shiva EmamiDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Marie HennebelleDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Rhianna K MorganDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Larry A LernoFood Safety and Measurement Facility, University of California, Davis, CA, USA.
Carolyn M SlupskyDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA; Department of Nutrition, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: ataha@ucdavis.edu.
University of California, Davis · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
Role of early postnatal exposure to non-persistent pesticides through breast milk on neurodevelopmentR21ES032990 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TAHA, AMEER · 2022 to 2023
$432k
Role of excess maternal linoleic acid intake on infant neurodevelopmentR21HD095391 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TAHA, AMEER · 2019 to 2020
$432k
NICHD NIH HHS R21 HD095391NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R21 ES032990
6 · The paper itself

Abstract

Linoleic acid (LNA)-derived 13-hydroxyoctadecadienoic acid (13-HODE) is a bioactive lipid mediator that regulates multiple signaling processes in vivo. 13-HODE is also produced when LNA is oxidized during food processing. However, the absorption and incorporation kinetics of dietary 13-HODE into tissues is not known. The present study measured unesterified d4-13-HODE plasma bioavailability and incorporation into rat liver, adipose, heart and brain following gavage or intravenous (IV) injection (n = 3 per group). Mass spectrometry analysis revealed that d4-13-HODE was absorbed within 20 min of gavage, and continued to incorporate into plasma esterified lipid fractions throughout the 90 min monitoring period (incorporation half-life of 71 min). Following IV injection, unesterified d4-13-HODE was rapidly eliminated from plasma with a half-life of 1 min. Analysis of tracer incorporation kinetics into rat tissues following IV injection or gavage revealed that the esterified tracer preferentially incorporated into liver, adipose and heart compared to unesterified d4-13-HODE. No tracer was detected in the brain. This study demonstrates that dietary 13-HODE is absorbed, and incorporated into peripheral tissues from esterified plasma lipid pools. Understanding the chronic effects of dietary 13-HODE exposure on peripheral tissue physiology and metabolism merits future investigation.

Indexed as

Adipose TissueAnimalsBrainEsterificationLinoleic AcidLinoleic AcidsLiverMaleMyocardiumRatsRats, Inbred F34413-hydroxy-9,11-octadecadienoic acidLinoleic AcidLinoleic AcidsAdipose tissueBrainHeartKineticsLiverOxidized linoleic acid metabolites (OXLAMs)

Identifiers

PMID33340768
PMCPMC7979545
OpenAlexW3112062096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.